Version 1
: Received: 22 April 2024 / Approved: 22 April 2024 / Online: 23 April 2024 (13:11:51 CEST)
How to cite:
Dembitsky, V.M. Highly Oxygenated Cyclobutane Ring in Biomolecules: Insights into Structure and Activity. Preprints2024, 2024041471. https://doi.org/10.20944/preprints202404.1471.v1
Dembitsky, V.M. Highly Oxygenated Cyclobutane Ring in Biomolecules: Insights into Structure and Activity. Preprints 2024, 2024041471. https://doi.org/10.20944/preprints202404.1471.v1
Dembitsky, V.M. Highly Oxygenated Cyclobutane Ring in Biomolecules: Insights into Structure and Activity. Preprints2024, 2024041471. https://doi.org/10.20944/preprints202404.1471.v1
APA Style
Dembitsky, V.M. (2024). Highly Oxygenated Cyclobutane Ring in Biomolecules: Insights into Structure and Activity. Preprints. https://doi.org/10.20944/preprints202404.1471.v1
Chicago/Turabian Style
Dembitsky, V.M. 2024 "Highly Oxygenated Cyclobutane Ring in Biomolecules: Insights into Structure and Activity" Preprints. https://doi.org/10.20944/preprints202404.1471.v1
Abstract
This review explores the unique structural and functional characteristics of natural products featuring highly oxygenated cyclobutane rings, with a specific focus on oxetane and 1,2-dioxetane motifs. It presents the structures and biological activities of compounds containing these rings, highlighting their contribution to molecular stability and pharmacological potency. Through detailed case studies and recent research findings, it has been demonstrated that these oxygen-rich rings enhance the molecular diversity and biological efficacy of natural products, potentially offering new avenues for drug development. Notably, these compounds are predominantly synthesized by microorganisms and can also be found in extracts from fungi, plants, and certain marine invertebrates. Compounds with oxetane and 1,2-dioxetane rings are primarily noted for their strong antineoplastic properties, among other biological activities. In contrast, most 1,2-dioxetanes exhibit potent antiprotozoal effects. It is important to note that 1,2-dioxetanes often serve as intermediate products in oxidation reactions, characterized by their instability and propensity to decompose into new compounds.
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
