MD, M.G.B.; BS, D.J.B.; BS, K.M.H.; BS, K.A.H.; MPH, A.S.O.M.; PhD, X.M.M. Stem Cells and Acellular Preparations in Bone Regeneration/Fracture Healing: Current Therapies and Future Directions. Preprints2024, 2024040582. https://doi.org/10.20944/preprints202404.0582.v1
APA Style
MD, M.G.B., BS, D.J.B., BS, K.M.H., BS, K.A.H., MPH, A.S.O.M., & PhD, X.M.M. (2024). Stem Cells and Acellular Preparations in Bone Regeneration/Fracture Healing: Current Therapies and Future Directions. Preprints. https://doi.org/10.20944/preprints202404.0582.v1
Chicago/Turabian Style
MD, M.G.B., Ayobami S. Ogunsola MD MPH and Xue Ma MD PhD. 2024 "Stem Cells and Acellular Preparations in Bone Regeneration/Fracture Healing: Current Therapies and Future Directions" Preprints. https://doi.org/10.20944/preprints202404.0582.v1
Abstract
Bone/fracture healing is a complex process with different steps and four basic tissue layers being affected: cortical bone, periosteum, fascial tissue surrounding the fracture, and bone marrow. Stem cells and their derivatives, including embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, hematopoietic stem cells, skeletal stem cells, and multipotent stem cells, can function to artificially introduce highly regenerative cells into decrepit biological tissues and augment the healing process at the tissue level. Stem cells are molecularly and functionally indistinguishable from standard human tissues. The widespread appeal of stem cell therapy lies in its potential benefits as a therapeutic technology that, if harnessed, can be applied in clinical settings. This review aims to establish the molecular pathophysiology of bone healing, the current stem cell interventions that disrupt or augment the bone healing process, and finally, consider the future direction/therapeutic options related to stem cells and bone healing.
Keywords
stem cells; bone regeneration; fracture healing
Subject
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
