Version 1
: Received: 7 April 2024 / Approved: 8 April 2024 / Online: 8 April 2024 (15:40:08 CEST)
How to cite:
Chiodini, B.; Guillaume-Gentil, P.; Vanhomwegen, C.; Hennaut, E.; Lolin, K.; Tram, N.; Le Moine, A.; Ismaili, K. BK Polyomavirus in Pediatric Renal Transplantation. What We Know and What We Don’t.. Preprints2024, 2024040564. https://doi.org/10.20944/preprints202404.0564.v1
Chiodini, B.; Guillaume-Gentil, P.; Vanhomwegen, C.; Hennaut, E.; Lolin, K.; Tram, N.; Le Moine, A.; Ismaili, K. BK Polyomavirus in Pediatric Renal Transplantation. What We Know and What We Don’t.. Preprints 2024, 2024040564. https://doi.org/10.20944/preprints202404.0564.v1
Chiodini, B.; Guillaume-Gentil, P.; Vanhomwegen, C.; Hennaut, E.; Lolin, K.; Tram, N.; Le Moine, A.; Ismaili, K. BK Polyomavirus in Pediatric Renal Transplantation. What We Know and What We Don’t.. Preprints2024, 2024040564. https://doi.org/10.20944/preprints202404.0564.v1
APA Style
Chiodini, B., Guillaume-Gentil, P., Vanhomwegen, C., Hennaut, E., Lolin, K., Tram, N., Le Moine, A., & Ismaili, K. (2024). BK Polyomavirus in Pediatric Renal Transplantation. What We Know and What We Don’t.. Preprints. https://doi.org/10.20944/preprints202404.0564.v1
Chicago/Turabian Style
Chiodini, B., Alain Le Moine and Khalid Ismaili. 2024 "BK Polyomavirus in Pediatric Renal Transplantation. What We Know and What We Don’t." Preprints. https://doi.org/10.20944/preprints202404.0564.v1
Abstract
BK polyomavirus (BKPyV) is still a real threat in the management of kidney transplantation. Immunosuppressive treatment disrupts the equilibrium between virus replication and immune response, and uncontrolled BKPyV replication leads to nephropathy (BKPyV nephropathy). The first evidence of BKPyV reactivation in transplant recipients is the detection of viral shedding in urine, which appears in 20% to 60% of patients, followed by BKPyV viremia in 10-20% of kidney transplant recipients. BKPyV nephropathy eventually occurs in 1-10% of this population, mainly within the first 2 years post-transplantation, causing graft loss in about half of those patients. Few data exist regarding the pediatric population and we focus on them.
In this paper, we review the existing diagnostic methods, we summarize the evidences on the role of BKPyV humoral and cellular immunity in the modulation of the clinical course of BKPyV infection and as potential predictors of the outcome. We look at the known risk factors of BKPyV nephropathy in the immunosuppressed patient. Finally, we propose a sensible clinical attitude in order to screen and manage BKPyV infection in kidney transplant children.
Keywords
BK polyomavirus; BKPyV nephropathy; kidney transplantation
Subject
Medicine and Pharmacology, Urology and Nephrology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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