Version 1
: Received: 4 April 2024 / Approved: 5 April 2024 / Online: 5 April 2024 (11:01:42 CEST)
How to cite:
Rutkis, R.; Lasa, Z.; Rubina, M.; Strazdina, I.; Kalnenieks, U. Eminent Antimicrobial Peptide Resistance in Zymomonas mobilis: A Novel Advantage of Intrinsically Uncoupled Energetics. Preprints2024, 2024040413. https://doi.org/10.20944/preprints202404.0413.v1
Rutkis, R.; Lasa, Z.; Rubina, M.; Strazdina, I.; Kalnenieks, U. Eminent Antimicrobial Peptide Resistance in Zymomonas mobilis: A Novel Advantage of Intrinsically Uncoupled Energetics. Preprints 2024, 2024040413. https://doi.org/10.20944/preprints202404.0413.v1
Rutkis, R.; Lasa, Z.; Rubina, M.; Strazdina, I.; Kalnenieks, U. Eminent Antimicrobial Peptide Resistance in Zymomonas mobilis: A Novel Advantage of Intrinsically Uncoupled Energetics. Preprints2024, 2024040413. https://doi.org/10.20944/preprints202404.0413.v1
APA Style
Rutkis, R., Lasa, Z., Rubina, M., Strazdina, I., & Kalnenieks, U. (2024). Eminent Antimicrobial Peptide Resistance in Zymomonas mobilis: A Novel Advantage of Intrinsically Uncoupled Energetics. Preprints. https://doi.org/10.20944/preprints202404.0413.v1
Chicago/Turabian Style
Rutkis, R., Inese Strazdina and Uldis Kalnenieks. 2024 "Eminent Antimicrobial Peptide Resistance in Zymomonas mobilis: A Novel Advantage of Intrinsically Uncoupled Energetics" Preprints. https://doi.org/10.20944/preprints202404.0413.v1
Abstract
Relative to several model bacteria, the ethanologenic bacterium Zymomonas mobilis is shown here to have an elevated resistance to exogenous antimicrobial peptides (AMPs) – both, with regard to peptide bulk concentration in the medium, and the numbers of peptide molecules per cell. By monitoring integration of the AMPs in the bacterial cell membrane and observing the resulting effect on membrane energy-coupling, it is concluded that the membranotropic effects of the tested AMPs in Z. mobilis and in Escherichia coli are comparable. The advantage of Z. mobilis over E. coli apparently results from its uncoupled mode of energy metabolism that, in contrast to E. coli, does not rely on oxidative phosphorylation, and hence, is less vulnerable to disruption of its energy-coupling membrane by AMPs. It is concluded that the high resistance to antimicrobial peptides (AMPs) observed in Z. mobilis not only proves crucial for its survival in its natural environment but also offers a promising platform for AMP production and sheds light on potential strategies for novel resistance development in clinical settings.
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
