Version 1
: Received: 2 April 2024 / Approved: 3 April 2024 / Online: 4 April 2024 (17:32:20 CEST)
How to cite:
MERINO-GOYENECHEA, J.; PALACIOS-ALBERTI, J.; YANES-MARTÍNEZ, T.; MARTÍNEZ-VALLADARES, M.; BALAÑA-FOUCE, R. Treatment and healing of Leishmaniasis in a Wolf in Semi-captivity Regime from an Educational Center of Zamora Province (Spain). Preprints2024, 2024040350. https://doi.org/10.20944/preprints202404.0350.v1
MERINO-GOYENECHEA, J.; PALACIOS-ALBERTI, J.; YANES-MARTÍNEZ, T.; MARTÍNEZ-VALLADARES, M.; BALAÑA-FOUCE, R. Treatment and healing of Leishmaniasis in a Wolf in Semi-captivity Regime from an Educational Center of Zamora Province (Spain). Preprints 2024, 2024040350. https://doi.org/10.20944/preprints202404.0350.v1
MERINO-GOYENECHEA, J.; PALACIOS-ALBERTI, J.; YANES-MARTÍNEZ, T.; MARTÍNEZ-VALLADARES, M.; BALAÑA-FOUCE, R. Treatment and healing of Leishmaniasis in a Wolf in Semi-captivity Regime from an Educational Center of Zamora Province (Spain). Preprints2024, 2024040350. https://doi.org/10.20944/preprints202404.0350.v1
APA Style
MERINO-GOYENECHEA, J., PALACIOS-ALBERTI, J., YANES-MARTÍNEZ, T., MARTÍNEZ-VALLADARES, M., & BALAÑA-FOUCE, R. (2024). Treatment and healing of Leishmaniasis in a Wolf in Semi-captivity Regime from an Educational Center of Zamora Province (Spain). Preprints. https://doi.org/10.20944/preprints202404.0350.v1
Chicago/Turabian Style
MERINO-GOYENECHEA, J., MARÍA MARTÍNEZ-VALLADARES and RAFAEL BALAÑA-FOUCE. 2024 "Treatment and healing of Leishmaniasis in a Wolf in Semi-captivity Regime from an Educational Center of Zamora Province (Spain)" Preprints. https://doi.org/10.20944/preprints202404.0350.v1
Abstract
Leishmaniasis in wild canids is a vector-borne disease caused in Europe by the protozoan parasite Leishmania infantum. To date, there is limited information on clinical signs and laboratory abnormalities in wolves due to leishmaniasis. The current clinical case report described a female Iberian wolf (Canis lupus signatus) housed in semi-captivity conditions at the Centro del Lobo Ibérico “Félix Rodríguez de la Fuente”, in Robledo de Sanabria, Zamora (Spain) with an interdigital ulcerous wound at the right forepaw, hyper-gammaglobulinemia, and abnormal liver blood parameters. Definitive serodiagnosis of leishmaniasis was established using antileishmanial serum antibodies and PCR analysis of different biological samples. A gold standard anti-L. infantum treatment protocol consisting in intramuscular meglumine antimoniate and oral allopurinol combination was installed. However, the presence of pain at the site of injection due to meglumine antimoniate administration forced its substitution by oral miltefosine. A progressive reduction of the levels of anti-L. infantum serum antibodies and the concentrations of gamma-globulin fraction was detected after antileishmanial treatment as well as a decline of liver GPT. To our knowledge, this is the first case of leishmaniasis diagnosed in a wolf housed in semi-captivity conditions treated and successfully cured.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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