Covello, C.; Di Vincenzo, F.; Cammarota, G.; Pizzoferrato, M. Micro(Nano)Plastics and Their Potential Impact on Human Gut Health: A Narrative Review. Current Issues in Molecular Biology 2024, 46, 2658–2677, doi:10.3390/cimb46030168.
Covello, C.; Di Vincenzo, F.; Cammarota, G.; Pizzoferrato, M. Micro(Nano)Plastics and Their Potential Impact on Human Gut Health: A Narrative Review. Current Issues in Molecular Biology 2024, 46, 2658–2677, doi:10.3390/cimb46030168.
Covello, C.; Di Vincenzo, F.; Cammarota, G.; Pizzoferrato, M. Micro(Nano)Plastics and Their Potential Impact on Human Gut Health: A Narrative Review. Current Issues in Molecular Biology 2024, 46, 2658–2677, doi:10.3390/cimb46030168.
Covello, C.; Di Vincenzo, F.; Cammarota, G.; Pizzoferrato, M. Micro(Nano)Plastics and Their Potential Impact on Human Gut Health: A Narrative Review. Current Issues in Molecular Biology 2024, 46, 2658–2677, doi:10.3390/cimb46030168.
Abstract
: Microplastics and nanoplastics (MNPs) are becoming an increasingly severe global problem due to their widespread distribution and complex impact on living organisms. Apart from their environmental impact, the effects of MNPs on living organisms have also continued to attract attention. The harmful impact of MNPs has been extensively documented in marine invertebrates and larger marine vertebrates like fish. However, the research on the toxicity of these particles on mammals is still limited, and their possible effects on humans are poorly understood. Considering that MNPs are commonly found in food or food packaging, humans are primarily exposed to them through ingestion. It would be valuable to investigate the potential harmful effects of these particles on gut health. This review focuses on recent research exploring the toxicological impacts of micro- and nanoplastics on the gut, as observed in human cell lines and mammalian models. Available data from various studies indicate that the accumulation of MNPs in mammalian models and human cells may result in adverse consequences, in terms of epithelial toxicity, immune toxicity, and disruption of gut microbiota. The paper also discusses the current research limitations and prospects in this field, aiming to provide a scientific basis and reference for further studies on the toxic mechanisms of micro- and nanoplastics.
Keywords
digestive system; gut microbiota; human cells; intestinal toxicity; microplastics; mouse models; nanoplastics; plastic; polymers
Subject
Biology and Life Sciences, Other
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
