Version 1
: Received: 12 March 2024 / Approved: 13 March 2024 / Online: 14 March 2024 (07:42:46 CET)
How to cite:
Mizrahi, R.; Ostersetzer-Biran, O. Organellar RNA Helicases as Key Tools in Plant Organellar RNA Splicing and Regulation of Gene Expression. Preprints2024, 2024030790. https://doi.org/10.20944/preprints202403.0790.v1
Mizrahi, R.; Ostersetzer-Biran, O. Organellar RNA Helicases as Key Tools in Plant Organellar RNA Splicing and Regulation of Gene Expression. Preprints 2024, 2024030790. https://doi.org/10.20944/preprints202403.0790.v1
Mizrahi, R.; Ostersetzer-Biran, O. Organellar RNA Helicases as Key Tools in Plant Organellar RNA Splicing and Regulation of Gene Expression. Preprints2024, 2024030790. https://doi.org/10.20944/preprints202403.0790.v1
APA Style
Mizrahi, R., & Ostersetzer-Biran, O. (2024). Organellar RNA Helicases as Key Tools in Plant Organellar RNA Splicing and Regulation of Gene Expression. Preprints. https://doi.org/10.20944/preprints202403.0790.v1
Chicago/Turabian Style
Mizrahi, R. and Oren Ostersetzer-Biran. 2024 "Organellar RNA Helicases as Key Tools in Plant Organellar RNA Splicing and Regulation of Gene Expression" Preprints. https://doi.org/10.20944/preprints202403.0790.v1
Abstract
Mitochondria are semiautonomous organelles, which are pivotal for the energy metabolism of eukaryotic cells. These organelles contain their own genetic system (mtDNA, mitogenome) that encodes to some structural RNAs and organellar proteins. The biogenesis and function of mitochondria is tightly regulated by nuclear-encoded protein cofactors. The mtDNAs of land plants are characteristically large, with a complex mode of gene organization and expression, in particularly at the post-transcriptional level. To become functional, the primary organellar transcripts undergo extensive maturation steps, which include endo- and exo-nucleolytic cleavage, RNA-base editing, and both ‘cis’- and ‘trans’-splicing events. These essential processing steps rely on the activities of a large set of nuclear-encoded factors. Among these, the RNA helicases serve as key players in organellar (mt-)RNA metabolism. This review summarizes the important roles played by these factors in regulating the highly dynamic processes of transcription, RNA processing, and translation within the mitochondria of land plants. We further discuss recent advancements in understanding how dysregulation of mitochondrial RNA helicases affects the organellar gene expression, respiratory functions, and hence the growth, development and physiology of land plants.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
