Version 1
: Received: 5 March 2024 / Approved: 6 March 2024 / Online: 6 March 2024 (10:56:58 CET)
How to cite:
Homan, K.; Onodera, T.; Matsuoka, M.; Iwasaki, N. Glycosphingolipids in Osteoarthritis and Cartilage Regeneration Therapy: Mechanisms and Therapeutic Prospects. Preprints2024, 2024030303. https://doi.org/10.20944/preprints202403.0303.v1
Homan, K.; Onodera, T.; Matsuoka, M.; Iwasaki, N. Glycosphingolipids in Osteoarthritis and Cartilage Regeneration Therapy: Mechanisms and Therapeutic Prospects. Preprints 2024, 2024030303. https://doi.org/10.20944/preprints202403.0303.v1
Homan, K.; Onodera, T.; Matsuoka, M.; Iwasaki, N. Glycosphingolipids in Osteoarthritis and Cartilage Regeneration Therapy: Mechanisms and Therapeutic Prospects. Preprints2024, 2024030303. https://doi.org/10.20944/preprints202403.0303.v1
APA Style
Homan, K., Onodera, T., Matsuoka, M., & Iwasaki, N. (2024). Glycosphingolipids in Osteoarthritis and Cartilage Regeneration Therapy: Mechanisms and Therapeutic Prospects. Preprints. https://doi.org/10.20944/preprints202403.0303.v1
Chicago/Turabian Style
Homan, K., Masatake Matsuoka and Norimasa Iwasaki. 2024 "Glycosphingolipids in Osteoarthritis and Cartilage Regeneration Therapy: Mechanisms and Therapeutic Prospects" Preprints. https://doi.org/10.20944/preprints202403.0303.v1
Abstract
Glycosphingolipids (GSLs), a subtype of glycolipids containing sphingosine, are critical components of vertebrate plasma membranes, playing a pivotal role in cellular signaling and interactions. In human articular cartilage in osteoarthritis (OA), GSL expression is known notably to decrease. This review focuses on the roles of gangliosides, a specific type of GSL, in cartilage degeneration and regeneration, emphasizing their regulatory function in signal transduction. The expression of gangliosides, whether endogenous or augmented exogenously, is regulated at the enzymatic level, targeting specific glycosyltransferases. This regulation has significant implications for the composition of cell surface gangliosides and their impact on signal transduction in chondrocytes and progenitor cells. Different levels of ganglioside expression can influence signaling pathways in various ways, potentially affecting cell properties, including malignancy. Moreover, gene manipulations against gangliosides have been shown to regulate cartilage metabolism and chondrocyte differentiation in vivo and in vitro. This review highlights the potential of targeting gangliosides in the development of therapeutic strategies for osteoarthritis and cartilage injury and addresses promising directions for future research and treatment.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
