Advanced-Glycation End Products-Selective Probe Development

Heewon Cho; Na-Kyeong Hong; Insung Yong; Haw-Young Kwon; Nam-Young Kang; Larissa Miasiro Ciaramicoli; Pilnam Kim; Young-Tae Chang

doi:10.20944/preprints202402.1624.v1

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preprints.org > chemistry and materials science > other > doi: 10.20944/preprints202402.1624.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Advanced-Glycation End Products-Selective Probe Development

Larissa Miasiro Ciaramicoli

Pilnam Kim

Young-Tae Chang

Version 1 : Received: 28 February 2024 / Approved: 28 February 2024 / Online: 28 February 2024 (10:42:58 CET)

How to cite: Cho, H.; Hong, N.; Yong, I.; Kwon, H.; Kang, N.; Ciaramicoli, L.M.; Kim, P.; Chang, Y. Advanced-Glycation End Products-Selective Probe Development. Preprints 2024, 2024021624. https://doi.org/10.20944/preprints202402.1624.v1 Cho, H.; Hong, N.; Yong, I.; Kwon, H.; Kang, N.; Ciaramicoli, L.M.; Kim, P.; Chang, Y. Advanced-Glycation End Products-Selective Probe Development. Preprints 2024, 2024021624. https://doi.org/10.20944/preprints202402.1624.v1

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MDPI and ACS Style

Cho, H.; Hong, N.; Yong, I.; Kwon, H.; Kang, N.; Ciaramicoli, L.M.; Kim, P.; Chang, Y. Advanced-Glycation End Products-Selective Probe Development. Preprints 2024, 2024021624. https://doi.org/10.20944/preprints202402.1624.v1

APA Style

Cho, H., Hong, N., Yong, I., Kwon, H., Kang, N., Ciaramicoli, L.M., Kim, P., & Chang, Y. (2024). Advanced-Glycation End Products-Selective Probe Development. Preprints. https://doi.org/10.20944/preprints202402.1624.v1

Chicago/Turabian Style

Cho, H., Pilnam Kim and Young-Tae Chang. 2024 "Advanced-Glycation End Products-Selective Probe Development" Preprints. https://doi.org/10.20944/preprints202402.1624.v1

Abstract

Advanced glycation end products (AGEs) play a significant role in the aging processes, further regarding as a hallmark of aging. Despite the importance, a lack of monitoring tools has hampered the study of relationship between AGEs and aging. Here, we firstly report a novel AGEs-selective probe, AGO. AGO presented its ability to detect AGEs more sensitively than a conventional approach of measuring autofluorescence from AGEs. In addition, we confirmed that AGO can detect AGEs depending on kinetics, reflecting by a preference to ribose-derived AGEs. Finally, AGO revealed its competence to visualize glycation products in glycation mimicking model, made by collagen framework. We believe that this study will enrich molecular toolboxes to understand physiological processes of AGEs during aging processes.

Keywords

Advanced glycation products; fluorescence small molecule; Fluorescence library; Screening; Aging

Subject

Chemistry and Materials Science, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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