Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis – a Pilot Prospective Observational Cohort Study

Lazar A. Chisavu
ORCID logo ,
Viviana M. Ivan
ORCID logo ,
Adelina Mihaescu
* ORCID logo ,
Flavia Chisavu
ORCID logo ,
Oana Schiller
,
Luciana Marc
ORCID logo ,
Flaviu Bob
ORCID logo ,
Adalbert Schiller
ORCID logo
Version 1 : Received: 27 February 2024 / Approved: 28 February 2024 / Online: 28 February 2024 (13:52:38 CET)

A peer-reviewed article of this Preprint also exists.

Chisavu, L.; Ivan, V.M.; Mihaescu, A.; Chisavu, F.; Schiller, O.; Marc, L.; Bob, F.; Schiller, A. Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis—A Pilot Prospective Observational Cohort Study. Diagnostics 2024, 14, 664. Chisavu, L.; Ivan, V.M.; Mihaescu, A.; Chisavu, F.; Schiller, O.; Marc, L.; Bob, F.; Schiller, A. Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis—A Pilot Prospective Observational Cohort Study. Diagnostics 2024, 14, 664.

Abstract

Chronic kidney disease patients treated by hemodialysis present a high cardio-vascular morbidity and mortality. There is an imperative need for novel biomarkers in identifying and to offer possible therapeutically intervention in these patients. We performed a prospective observational cohort study on 77 patients in the period October 2021 – October 2023. We measured serum plasma levels of Interleukin 1-Beta, Galectin 3, human suppression of tumorigenicity factor 2, bone morphogenetic protein 2 and fibroblastic growth factor 23 at the inclusion. We evaluated the correlations of these biomarkers with cardiac function and structure evaluated by echocardiography. Mean age was 61.02 (±11.81) years, 45 (56.2%) males and with a dialysis vintage of 4.95 (2.4-7.8) years. Median ejection fraction was 51 (43-54 %) and more than two thirds of the patients presented valvular calcifications. Overall mortality was 22%. Interleukin 1-Beta correlated positively with ejection fraction and global longitudinal strain and negatively with left atrium diameter and left ventricle tele systolic diameter. Galectin 3 values negatively correlated with aortic valve fibrosis and mitral valve calcifications and human suppression tumorigenity factor 2 negatively correlated with mitral valve calcifications. Some of these novel biomarkers could be used to better asses the cardio-vascular disease in patients on maintenance hemodialysis.

Keywords

hemodialysis; mortality; cardio-vascular disease; novel biomarkers; cardiac function and structure

Subject

Medicine and Pharmacology, Internal Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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