Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effect of Neoadjuvant Chemotherapy on Tumor Infiltrating Lymphocytes in Resectable Gastric Cancer: Analysis from a Western Academic Center

Elliott J Yee
* ORCID logo ,
Danielle Gilbert
,
Jeffrey Kaplan
,
Sachin Wani
,
Sunnie S Kim
ORCID logo ,
Martin D McCarter
,
Camille L Stewart
Version 1 : Received: 26 February 2024 / Approved: 27 February 2024 / Online: 27 February 2024 (09:28:15 CET)

A peer-reviewed article of this Preprint also exists.

Yee, E.J.; Gilbert, D.; Kaplan, J.; Wani, S.; Kim, S.S.; McCarter, M.D.; Stewart, C.L. Effect of Neoadjuvant Chemotherapy on Tumor-Infiltrating Lymphocytes in Resectable Gastric Cancer: Analysis from a Western Academic Center. Cancers 2024, 16, 1428. Yee, E.J.; Gilbert, D.; Kaplan, J.; Wani, S.; Kim, S.S.; McCarter, M.D.; Stewart, C.L. Effect of Neoadjuvant Chemotherapy on Tumor-Infiltrating Lymphocytes in Resectable Gastric Cancer: Analysis from a Western Academic Center. Cancers 2024, 16, 1428.

Abstract

Tumor infiltrating lymphocytes (TILs) are an emerging biomarker predictive of response to immunotherapy across a spectrum of solid organ malignancies. The characterization of TILs in gastric cancer (GC) treated with contemporary, multiagent neoadjuvant chemotherapy (NAC) is understudied. In this retrospective investigation, we analyzed the degree of infiltration, phenotype, and spatial distribution of TILs via immunohistochemistry within resected GC specimens treated with or without NAC at a Western center. We hypothesized that NAC executes immunostimulatory roles evidenced by an increased number of anti-tumor TILs in the tumor microenvironment. We found significantly elevated levels of conventional and memory CD8+ T cells, and total TILs (CD4+, CD8+, Treg, B cells) within chemotherapy-treated tumors compared to chemotherapy-naïve specimens. We also revealed important associations between survival and pathologic response with enhanced TIL infiltration. Taken together, our findings advocate for an immunostimulatory role of chemotherpy and underscore the potential synergistic effect of combining chemotherapy with immunotherapy in resectable gastric cancer.

Keywords

gastric cancer, tumor infiltrating lymphocytes, neoadjuvant therapy, immunotherapy

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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