Review
Version 1
Preserved in Portico This version is not peer-reviewed
Electrochemical Monitoring on Anticoagulation Therapy
Version 1
: Received: 23 February 2024 / Approved: 23 February 2024 / Online: 23 February 2024 (09:52:02 CET)
A peer-reviewed article of this Preprint also exists.
Mruthunjaya, A.K.V.; Torriero, A.A.J. Electrochemical Monitoring in Anticoagulation Therapy. Molecules 2024, 29, 1453. Mruthunjaya, A.K.V.; Torriero, A.A.J. Electrochemical Monitoring in Anticoagulation Therapy. Molecules 2024, 29, 1453.
Abstract
The process of blood coagulation, wherein circulating blood transforms into a clot in response to internal or external injury, is a critical physiological mechanism. Monitoring this coagulation process is vital to ensure that blood clotting occurs neither too rapidly nor too slowly. Anticoagulants, a category of medications designed to prevent and treat blood clots, require meticulous monitoring to optimise dosage, enhance clinical outcomes, and minimise adverse effects. This review article delves into the various stages of blood coagulation, explores commonly used anticoagulants and their targets within the coagulation enzyme system, and emphasises the electrochemical methods employed in anticoagulant testing. Electrochemical sensors for anticoagulant monitoring are categorised into two types. The first type focuses on assays measuring thrombin activity via electrochemical techniques. The second type involves modified electrode surfaces that either directly measure the redox behaviour of anticoagulants or monitor the response of standard redox probes in the presence of these drugs. The review provides a comprehensive list of different electrode compositions and their detection and quantification limits. Additionally, it discusses the potential of employing a universal calibration plot to replace individual drug-specific calibrations. The insights presented are anticipated to significantly contribute to the sensor community's efforts in this field.
Keywords
Electrochemical sensors; coagulation; anticoagulants; point-of-care; thrombin; factor Xa.
Subject
Chemistry and Materials Science, Electrochemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
