Oh, S.W.; Kim, S.K.; Ahn, B.J.; Yim, S.K.; Yang, S.H. Effects of Potential Prebiotics from Codiumfragile on Intestinal Diseases. Appl. Sci.2024, 14, 3037.
Oh, S.W.; Kim, S.K.; Ahn, B.J.; Yim, S.K.; Yang, S.H. Effects of Potential Prebiotics from Codium fragile on Intestinal Diseases. Appl. Sci. 2024, 14, 3037.
Oh, S.W.; Kim, S.K.; Ahn, B.J.; Yim, S.K.; Yang, S.H. Effects of Potential Prebiotics from Codiumfragile on Intestinal Diseases. Appl. Sci.2024, 14, 3037.
Oh, S.W.; Kim, S.K.; Ahn, B.J.; Yim, S.K.; Yang, S.H. Effects of Potential Prebiotics from Codium fragile on Intestinal Diseases. Appl. Sci. 2024, 14, 3037.
Abstract
Codium fragile, a green algae, exhibit biological properties. In this study, we examined the effect of Codium fragile extract (CFE) on dextran sulfate sodium (DSS)-induced colitis. As the administration of CFE increased, the proliferation of Akkermansia muciniphila, which is key player in metabolic and gastrointestinal disorders, increased. After CFE administration for 10 weeks, acetic acid was revealed as the major metabolite in mouse cecum and β-glucuronidase activity in mouse feces is decreased. Further, CFE significantly alleviates the acute intestinal injury induced by DSS administration, including DAI scores and colon length. MPO activity in the colon was significantly reduced in the CFE-fed group, which indicated that CFE could inhibit neutrophils infiltration and inflammation in mice. In conclusion, a protective effect of CFE against DSS colitis suggests its clinical use for IBD patients.
Biology and Life Sciences, Biology and Biotechnology
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