Domènech-Montoliu, S.; Puig-Barberà, J.; Pac-Sa, M.R.; Orrico-Sanchéz, A.; Gómez-Lanas, L.; Sala-Trull, D.; Domènech-Leon, C.; Del Rio-González, A.; Sánchez-Urbano, M.; Satorres-Martinez, P.; Aparisi-Esteve, L.; Badenes-Marques, G.; Blasco-Gari, R.; Casanova-Suarez, J.; Gil-Fortuño, M.; Hernández-Pérez, N.; Jovani-Sales, D.; López-Diago, L.; Notari-Rodríguez, C.; Pérez-Olaso, O.; Romeu-Garcia, M.A.; Ruíz-Puig, R.; Arnedo-Pena, A. Cellular Immunity of SARS-CoV-2 in the Borriana COVID-19 Cohort: A Nested Case–Control Study. Epidemiologia2024, 5, 167-186.
Domènech-Montoliu, S.; Puig-Barberà, J.; Pac-Sa, M.R.; Orrico-Sanchéz, A.; Gómez-Lanas, L.; Sala-Trull, D.; Domènech-Leon, C.; Del Rio-González, A.; Sánchez-Urbano, M.; Satorres-Martinez, P.; Aparisi-Esteve, L.; Badenes-Marques, G.; Blasco-Gari, R.; Casanova-Suarez, J.; Gil-Fortuño, M.; Hernández-Pérez, N.; Jovani-Sales, D.; López-Diago, L.; Notari-Rodríguez, C.; Pérez-Olaso, O.; Romeu-Garcia, M.A.; Ruíz-Puig, R.; Arnedo-Pena, A. Cellular Immunity of SARS-CoV-2 in the Borriana COVID-19 Cohort: A Nested Case–Control Study. Epidemiologia 2024, 5, 167-186.
Domènech-Montoliu, S.; Puig-Barberà, J.; Pac-Sa, M.R.; Orrico-Sanchéz, A.; Gómez-Lanas, L.; Sala-Trull, D.; Domènech-Leon, C.; Del Rio-González, A.; Sánchez-Urbano, M.; Satorres-Martinez, P.; Aparisi-Esteve, L.; Badenes-Marques, G.; Blasco-Gari, R.; Casanova-Suarez, J.; Gil-Fortuño, M.; Hernández-Pérez, N.; Jovani-Sales, D.; López-Diago, L.; Notari-Rodríguez, C.; Pérez-Olaso, O.; Romeu-Garcia, M.A.; Ruíz-Puig, R.; Arnedo-Pena, A. Cellular Immunity of SARS-CoV-2 in the Borriana COVID-19 Cohort: A Nested Case–Control Study. Epidemiologia2024, 5, 167-186.
Domènech-Montoliu, S.; Puig-Barberà, J.; Pac-Sa, M.R.; Orrico-Sanchéz, A.; Gómez-Lanas, L.; Sala-Trull, D.; Domènech-Leon, C.; Del Rio-González, A.; Sánchez-Urbano, M.; Satorres-Martinez, P.; Aparisi-Esteve, L.; Badenes-Marques, G.; Blasco-Gari, R.; Casanova-Suarez, J.; Gil-Fortuño, M.; Hernández-Pérez, N.; Jovani-Sales, D.; López-Diago, L.; Notari-Rodríguez, C.; Pérez-Olaso, O.; Romeu-Garcia, M.A.; Ruíz-Puig, R.; Arnedo-Pena, A. Cellular Immunity of SARS-CoV-2 in the Borriana COVID-19 Cohort: A Nested Case–Control Study. Epidemiologia 2024, 5, 167-186.
Abstract
Our goal was to determine the cellular immune response (CIR) among a random sample of the Borriana COVID-19 cohort (Spain) to identify its associated factors and their relationship with infection, reinfection and sequelae. We conducted a nested case-control study using a randomly selected sample of 225 individuals age 18 and older, including 36 individual naïve to SARS-CoV-2 infection, and 189 infected patients. We employed flow cytometry-based immunoassays for intracellular cytokine staining, utilizing Wuhan and BA.2 antigens and chemoluminescence microparticle immunoassay for detection SARS-CoV-2 antibodies. Logistic regression models were used. A total of 215 (95.6%) participants exhibited T-cell response (TCR) to at least one antigen. Positive responses of CD4+ and CD8+ T cells were 89.8% and 85.3% respectively. No difference in CIR was found for naïve and infected patients. Patients who experienced sequelae exhibited higher CIR than those without. A positive correlation was observed between TCR and Anti-Spike IgG levels. Factors positive associated with TCR included A-blood group, number of SARS-CoV-2 vaccine doses received, and Anti-N IgM; factors inversely related were the time elapsed since the last vaccine dose or infection, and B-blood group. These findings contribute valuable insights into the nuance immune landscape shaped by SARS-CoV-2 infection and vaccination.
Medicine and Pharmacology, Epidemiology and Infectious Diseases
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