Li, F.; Liang, Y.; Lin, D.; Li, X.; Yang, L.; Cui, X.; Lou, D.; Yang, X. Microbial Transformation of Total Saponins from Panax notoginseng Flower by the Fungus Talaromyces flavus. Preprints2024, 2024021084. https://doi.org/10.20944/preprints202402.1084.v1
APA Style
Li, F., Liang, Y., Lin, D., Li, X., Yang, L., Cui, X., Lou, D., & Yang, X. (2024). Microbial Transformation of Total Saponins from Panax notoginseng Flower by the Fungus<em> Talaromyces flavus</em>. Preprints. https://doi.org/10.20944/preprints202402.1084.v1
Chicago/Turabian Style
Li, F., Dengji Lou and Xiaoyan Yang. 2024 "Microbial Transformation of Total Saponins from Panax notoginseng Flower by the Fungus<em> Talaromyces flavus</em>" Preprints. https://doi.org/10.20944/preprints202402.1084.v1
Abstract
Panax notoginseng is a traditional Chinese medicine, and saponins are its main active ingredients. The content of saponins in flower of P. notoginseng is the highest in the whole plant. Minor ginsenosides have stronger pharmacological activity than main ginsenosides, but its content in nature is very low. We can use extracted total saponins from P. notoginseng flower as the substrate to produce minor ginsenosides by biotransformation method. In this study, we used the fungus Talaromyces flavus and its crude enzymes to transform the extracted total saponins of P. notoginseng flower. Through the qualitative and quantitative analysis of the transformation substrates and products, it was found that minor ginsenosides Gyp-XVII, ginsenosides C-Mc1, C-Mx1, F2, Rg3, 20(R)-Rg3, Rk1 and Rg5 were found in the products and the conversion rate of the major saponins in P. notoginseng flower ranged from 44.16 to 55.22%, the yields of the minor ginsenosides ranged from 0.05 to 3.24%. This study provided a good experimental idea, greatly increased the utilization rate of total saponins in P. notoginseng flower, and laid a foundation for promoting the wide application of minor saponins.
Keywords
Panax notoginseng flower; total saponins; microbial transformation; Talaromyces flavus; minor ginsenosides
Subject
Chemistry and Materials Science, Analytical Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
