Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

In Vivo Absorption and Lymphatic Bioavailability of DHA from Microalgal Oil according to Its Physical and Chemical Form of Vectorization

Leslie Couëdelo
* ORCID logo ,
Stéphanie Lennon
* ,
Hélène Abrous
,
Ikram Chamekh
,
Corentin Bouju
,
Hugues Griffon
,
Carole Vaysse
,
Lionel Larvol
,
Gildas Breton
*
Version 1 : Received: 14 February 2024 / Approved: 14 February 2024 / Online: 14 February 2024 (11:28:24 CET)

A peer-reviewed article of this Preprint also exists.

Couëdelo, L.; Lennon, S.; Abrous, H.; Chamekh, I.; Bouju, C.; Griffon, H.; Vaysse, C.; Larvol, L.; Breton, G. In Vivo Absorption and Lymphatic Bioavailability of Docosahexaenoic Acid from Microalgal Oil According to Its Physical and Chemical Form of Vectorization. Nutrients 2024, 16, 1014. Couëdelo, L.; Lennon, S.; Abrous, H.; Chamekh, I.; Bouju, C.; Griffon, H.; Vaysse, C.; Larvol, L.; Breton, G. In Vivo Absorption and Lymphatic Bioavailability of Docosahexaenoic Acid from Microalgal Oil According to Its Physical and Chemical Form of Vectorization. Nutrients 2024, 16, 1014.

Abstract

Docosahexaenoic acid (DHA) is an essential fatty acid (FA) with proven health effects, whom bioavailability improvement is becoming a public health issue. Unlike fish oils, the bioavailability of DHA from microalgal (A) has not been fully assessed, particularly with regard to the molecular structuring capabilities offered by A-oil. We explored the impact of 5 formulas rich in DHA, different by i) the molecular structure: ethyl ester (EE) or monoglyceride (MG) or Triglyceride (TG) and ii) the supramolecular form: emulsified TG or TG+phospholipids (blend PL), on the lymphatic kinetics of DHA absorption and the lipid characteristics of resulting lipoproteins. We demonstrated that in rat, the DHA absorption of the conventional A-DHA TG structure was more effective than the EE structure (+ 23%). More, the A-DHA MG and A-DHA Emulsion were the most favourable DHA-vectors (AUC: 89% and +42%, respectively), thanks to an improved lipolysis. The A-DHA MG and -Emulsion presented the richest DHA content in TG (+40%) and PL (+50%) of lymphatic chylomicrons, which could impact the metabolic fate of DHA. We concluded that structuring A-DHA in TG or EE would be more prone for tissue and hepatic metabolism whereas in A-DHA MG and A-DHA Emulsion could target nerve tissues.

Keywords

fatty acid vectorization; lymph; enterocyte; lipids; microalgal oil; long chain omega-3; bioavailability; PUFA absorption; chylomicrons

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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