Review
Version 1
Preserved in Portico This version is not peer-reviewed
Brain-Derived Neurotrophic Factor, Nociception and Pain
Version 1
: Received: 8 February 2024 / Approved: 9 February 2024 / Online: 9 February 2024 (13:23:09 CET)
A peer-reviewed article of this Preprint also exists.
Merighi, A. Brain-Derived Neurotrophic Factor, Nociception, and Pain. Biomolecules 2024, 14, 539. Merighi, A. Brain-Derived Neurotrophic Factor, Nociception, and Pain. Biomolecules 2024, 14, 539.
Abstract
This review article discusses the involvement of the Brain-Derived Neurotrophic Factor (BDNF) in the control of pain. BDNF, a neurotrophin known for its essential role in neuronal survival and plasticity, has garnered significant attention for its potential implications as a modulator of nociception and pain. This comprehensive review aims to provide insights into the multifaceted interactions between BDNF and pain pathways, encompassing both physiological and pathological pain conditions. I delve into the molecular mechanisms underlying BDNF's involvement in pain processing and discuss potential therapeutic applications of BDNF and its mimetics in managing pain. Furthermore, I highlight recent advancements and challenges in translating BDNF-related research into clinical practice.
Keywords
BDNF; Nociception; Pain; Neurons; Glia; Presynaptic mechanisms; Postsynaptic mechanisms; LTP; Neuropeptides
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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