Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinicopathological and Genomic Identification of Breast Cancers with No Impact on Mortality

Salvador Gámez-Casado
ORCID logo ,
Lourdes Rodríguez-Pérez
,
Cristina Bandera-López
,
Andrés Mesas-Ruiz
,
Alicia Campini Bermejo
,
Marta Bernal-Gómez
,
Manuel Zalabardo-Aguilar
ORCID logo ,
Julio Calvete-Candenas
,
Gala Martínez-Bernal
,
Lidia Atienza-Cuevas
,
Marcial Garcia-Rojo
ORCID logo ,
Encarnación Benítez-Rodríguez
,
Bella Pajares-Hachero
,
María José Bermejo-Pérez
,
José Manuel Baena-Cañada
* ORCID logo
Version 1 : Received: 4 February 2024 / Approved: 5 February 2024 / Online: 5 February 2024 (16:30:40 CET)

A peer-reviewed article of this Preprint also exists.

Gámez-Casado, S.; Rodríguez-Pérez, L.; Bandera-López, C.; Mesas-Ruiz, A.; Campini-Bermejo, A.; Bernal-Gómez, M.; Zalabardo-Aguilar, M.; Calvete-Candenas, J.; Martínez-Bernal, G.; Atienza-Cuevas, L.; García-Rojo, M.; Benítez-Rodríguez, E.; Pajares-Hachero, B.; Bermejo-Pérez, M.J.; Baena-Cañada, J.M. Clinicopathological and Genomic Identification of Breast Cancers with No Impact on Mortality. Cancers 2024, 16, 1086. Gámez-Casado, S.; Rodríguez-Pérez, L.; Bandera-López, C.; Mesas-Ruiz, A.; Campini-Bermejo, A.; Bernal-Gómez, M.; Zalabardo-Aguilar, M.; Calvete-Candenas, J.; Martínez-Bernal, G.; Atienza-Cuevas, L.; García-Rojo, M.; Benítez-Rodríguez, E.; Pajares-Hachero, B.; Bermejo-Pérez, M.J.; Baena-Cañada, J.M. Clinicopathological and Genomic Identification of Breast Cancers with No Impact on Mortality. Cancers 2024, 16, 1086.

Abstract

Background. Implementing mammogram screening means that clinicians are seeing many breast cancers that will never develop metastases. The purpose of this study was to identify subgroups of breast cancer patients who did not present events related to long-term breast cancer mortality, taking into account diagnosis at breast screening, absence of palpability and axillary involvement, and genomic analysis with PAM50. Patients and Methods. To identify them, a retrospective observational study was carried out selecting patients without palpable tumour, without axillary involvement, and a genomic analysis was performed with PAM50. Results. The probability of distant metastasis-free interval (DMFI) of 337 patients was 0.92 (95% CI, 0.90-0.93) at 20 years and 0.96 (95% CI, 0.92-1.00) in 95 patients (28%) with available PAM50 tests. In 22 (23.15%) luminal A tumours and in 9 (9.47%) luminal B tumours smaller than 1 cm and in HER2 and basal type tumours there were no metastatic events (20-year DMFI of 1.00). Conclusion. Patients with nonpalpable breast cancer found at screening with negative nodes are at very low risk. It is possible to identify subgroups without metastatic events by determining the intrinsic subtype and tumour size less than 1 cm. De-escalation of treatment should be considered.

Keywords

Low-risk breast cancer; Metastasis; Observational study; Screening

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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