Review
Version 1
Preserved in Portico This version is not peer-reviewed
The Adaptive Immune Response against Bunyaviruses
Version 1
: Received: 2 February 2024 / Approved: 4 February 2024 / Online: 5 February 2024 (07:06:48 CET)
A peer-reviewed article of this Preprint also exists.
Alatrash, R.; Herrera, B.B. The Adaptive Immune Response against Bunyavirales. Viruses 2024, 16, 483. Alatrash, R.; Herrera, B.B. The Adaptive Immune Response against Bunyavirales. Viruses 2024, 16, 483.
Abstract
The Bunyavirales order includes at least fourteen families with diverse but related viruses, which are transmitted to vertebrate hosts by arthropod or rodent vectors. These viruses are responsible for an increasing number of outbreaks worldwide and represent a threat to public health. Infection in humans can be asymptomatic, or it may present with a range of conditions from a mild, febrile illness to severe hemorrhagic syndromes and/or neurological complications. There is a need to develop safe and effective vaccines, a process requiring better understanding of the adaptive immune responses involved during infection. This review highlights the most recent findings regarding T cell and antibody responses to the five bunyavirus families with known human pathogens (Peribunyaviridae, Phenuiviridae, Hantaviridae, Nairoviridae, and Arenaviridae). Future studies that define and characterize mechanistic correlates of protection against bunyavirus infections or disease will help inform the development of effective vaccines.
Keywords
T cells; antibodies; Bunyaviruses; Peribunyaviridae; Phenuiviridae; Hantaviridae; Nairoviridae; Arenaviridae
Subject
Biology and Life Sciences, Virology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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