Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

TBI and Tau Loss-of-Function Both Affect Naïve Ethanol Sensitivity in Drosophila

Valbona Hoxha
* ORCID logo ,
Gaurav Shrestha
,
Nayab Baloch
,
Sara Collevechio
,
Raegan R. Laszczyk
,
Gregg Roman
* ORCID logo
Version 1 : Received: 1 February 2024 / Approved: 2 February 2024 / Online: 2 February 2024 (10:36:33 CET)

A peer-reviewed article of this Preprint also exists.

Hoxha, V.; Shrestha, G.; Baloch, N.; Collevechio, S.; Laszczyk, R.; Roman, G. TBI and Tau Loss of Function Both Affect Naïve Ethanol Sensitivity in Drosophila. Int. J. Mol. Sci. 2024, 25, 3301. Hoxha, V.; Shrestha, G.; Baloch, N.; Collevechio, S.; Laszczyk, R.; Roman, G. TBI and Tau Loss of Function Both Affect Naïve Ethanol Sensitivity in Drosophila. Int. J. Mol. Sci. 2024, 25, 3301.

Abstract

Traumatic brain injury (TBI) is associated with alcohol abuse and higher ethanol sensitivity later in life. Currently, it is poorly understood how ethanol sensitivity changes with time after TBI and whether there are sex-dependent differences in the relationship between TBI and ethanol sensitivity. This study uses the fruit fly Drosophila melanogaster to investigate how TBI affects alcohol sensitivity and whether the effects are sex-specific. Our results indicate that flies have a significantly higher sensitivity to the intoxicating levels of ethanol during the acute phase post-TBI, regardless of sex. The increased ethanol sensitivity decreases as time progresses; however, females take longer than males to recover from the heightened ethanol sensitivity. Dietary restriction does not improve the negative effects of alcohol post-TBI. We found that tau mutant flies exhibit similar ethanol sensitivity to TBI flies. However, TBI increased the ethanol sensitivity of dtauKO mutants, suggesting that TBI and dTau loss-of-function have additive effects on ethanol sensitivty.

Keywords

TBI; Alcohol; Drosophila; Tau

Subject

Biology and Life Sciences, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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