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Simultaneous Detection of Dopamine and Uric Acid at a Glassy Carbon Electrode Modified with a Novel Polymerized Copper Phthalocyanine-Multi-Wall Carbon Nanotubes Complex
Version 1
: Received: 31 January 2024 / Approved: 1 February 2024 / Online: 1 February 2024 (10:51:03 CET)
How to cite:
Barhoumi, L.; Karker, O.; Nasraoui, S.; Ben Ali, M.; Kanoun, O. Simultaneous Detection of Dopamine and Uric Acid at a Glassy Carbon Electrode Modified with a Novel Polymerized Copper Phthalocyanine-Multi-Wall Carbon Nanotubes Complex. Preprints2024, 2024020033. https://doi.org/10.20944/preprints202402.0033.v1
Barhoumi, L.; Karker, O.; Nasraoui, S.; Ben Ali, M.; Kanoun, O. Simultaneous Detection of Dopamine and Uric Acid at a Glassy Carbon Electrode Modified with a Novel Polymerized Copper Phthalocyanine-Multi-Wall Carbon Nanotubes Complex. Preprints 2024, 2024020033. https://doi.org/10.20944/preprints202402.0033.v1
Barhoumi, L.; Karker, O.; Nasraoui, S.; Ben Ali, M.; Kanoun, O. Simultaneous Detection of Dopamine and Uric Acid at a Glassy Carbon Electrode Modified with a Novel Polymerized Copper Phthalocyanine-Multi-Wall Carbon Nanotubes Complex. Preprints2024, 2024020033. https://doi.org/10.20944/preprints202402.0033.v1
APA Style
Barhoumi, L., Karker, O., Nasraoui, S., Ben Ali, M., & Kanoun, O. (2024). Simultaneous Detection of Dopamine and Uric Acid at a Glassy Carbon Electrode Modified with a Novel Polymerized Copper Phthalocyanine-Multi-Wall Carbon Nanotubes Complex. Preprints. https://doi.org/10.20944/preprints202402.0033.v1
Chicago/Turabian Style
Barhoumi, L., Mounir Ben Ali and Olfa Kanoun. 2024 "Simultaneous Detection of Dopamine and Uric Acid at a Glassy Carbon Electrode Modified with a Novel Polymerized Copper Phthalocyanine-Multi-Wall Carbon Nanotubes Complex" Preprints. https://doi.org/10.20944/preprints202402.0033.v1
Abstract
The dopamine and uric acid are primary products of purine metabolism and they coexist in serum and the extracellular fluid of the central nervous system. Some diseases of the human body are due to abnormal levels of uric acid and dopamine. Thus, the clinical diagnosis of some diseases needs a sensitive and simultaneous analysis of uric acid and dopamine. In this study, a novel conductive composite film containing multi-walled carbon nanotubes (MWTs) with cooper phthalocyanine attached to acrylate polymer (MWCNTs-CuMAPC-PnBA) was fabricated and dropped on a glassy carbon electrode and used for the simultaneous determination of Uric Acid (UA) and dopamine (DA). The modified glassy carbon electrode showed satisfactory electrocatalytic activity toward dopamine and uric acid. Low detection limits were achieved at 0.174 µM of DA and 6.87 µM of UA and the linear detection ranges of DA and UA are 5-200 µM and 20-250 µM respectively. The proposed sensing system based on the modified GCE offers promising results for rapid, cost-effective and selective simultaneous detection of uric acid and dopamine. Also, the complex modified electrode showed satisfactory results to detecting simultaneously UA and DA in real human samples (human Urine) via the standard addition method.
Chemistry and Materials Science, Analytical Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
