Liao, H.-Y.; Yen, C.-M.; Hsiao, I.-H.; Hsu, H.-C.; Lin, Y.-W. Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model. Int. J. Mol. Sci.2024, 25, 2901.
Liao, H.-Y.; Yen, C.-M.; Hsiao, I.-H.; Hsu, H.-C.; Lin, Y.-W. Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model. Int. J. Mol. Sci. 2024, 25, 2901.
Liao, H.-Y.; Yen, C.-M.; Hsiao, I.-H.; Hsu, H.-C.; Lin, Y.-W. Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model. Int. J. Mol. Sci.2024, 25, 2901.
Liao, H.-Y.; Yen, C.-M.; Hsiao, I.-H.; Hsu, H.-C.; Lin, Y.-W. Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model. Int. J. Mol. Sci. 2024, 25, 2901.
Abstract
Pain is unpleasant sensory and emotional experience accompanied by tissue injury. Often an indi-vidual experience, it can be influenced by different physiological, psychological, and social factors. Fibromyalgia, one of the most difficult-to-treat types of pain, is characterized by general muscle pain accompanied by obesity, fatigue, sleep, and memory and psychological concerns. Fibromyal-gia has increased nociceptive sensations via central sensitization in the brain and spinal cord level. We used intermittent cold stress to create a mouse fibromyalgia pain model (Day 0: 3.69 0.14 g; Day 5: 2.13 0.12 g). Mechanical pain could be reversed by eicosapentaenoic acid (EPA) admin-istration (Day 0: 3.72 0.14 g; Day 5: 3.69 0.13 g). A similar trend could be also observed for thermal hyperalgesia. The levels of elements in the transient receptor potential V1 (TRPV1) sig-naling pathway were increased in the ascending pain pathway, including the thalamus, medial prefrontal cortex, somatosensory cortex, anterior cingulate cortex, and cerebellum. EPA intake significantly attenuated this overexpression. Novel chemogenetics method was used to indeed in-hibit SSC to ACC activity presented an analgesic effect through TRPV1 downstream pathway. The present results provide insights as to the role of TRPV1 signaling pathway as in fibromyalgia and its potential as a clinical target.
Biology and Life Sciences, Neuroscience and Neurology
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