Boff, J.M.; Shrestha, A.P.; Madireddy, S.; Viswaprakash, N.; Santina, L.D.; Vaithianathan, T. The Interplay between Neurotransmitters and Calcium Dynamics in Retinal Synapses during Development, Health, and Disease. Int. J. Mol. Sci.2024, 25, 2226.
Boff, J.M.; Shrestha, A.P.; Madireddy, S.; Viswaprakash, N.; Santina, L.D.; Vaithianathan, T. The Interplay between Neurotransmitters and Calcium Dynamics in Retinal Synapses during Development, Health, and Disease. Int. J. Mol. Sci. 2024, 25, 2226.
Boff, J.M.; Shrestha, A.P.; Madireddy, S.; Viswaprakash, N.; Santina, L.D.; Vaithianathan, T. The Interplay between Neurotransmitters and Calcium Dynamics in Retinal Synapses during Development, Health, and Disease. Int. J. Mol. Sci.2024, 25, 2226.
Boff, J.M.; Shrestha, A.P.; Madireddy, S.; Viswaprakash, N.; Santina, L.D.; Vaithianathan, T. The Interplay between Neurotransmitters and Calcium Dynamics in Retinal Synapses during Development, Health, and Disease. Int. J. Mol. Sci. 2024, 25, 2226.
Abstract
The intricate functionality of the vertebrate retina relies on the interplay between neurotransmitter activity and calcium dynamics, offering important insights into de-velopmental processes, physiological functioning, and disease progression. Neuro-transmitters orchestrate cellular processes to shape the behavior of the retina under diverse circumstances. Despite research to elucidate the roles of individual neuro-transmitters in the visual system, there remains a gap in our understanding of the holistic integration of their interplay with calcium dynamics in the broader context of neuronal development, health, and disease. To address this gap, the present review explores the mechanisms used by the neurotransmitters glutamate, GABA, glycine, dopamine, and acetylcholine and their interplay with calcium dynamics. This con-ceptual outline is intended to inform and guide future research, underpinning novel therapeutic avenues for retinal-associated disorders.
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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