Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Inflammatory Markers in Neonates Born to Mothers With SARS-CoV-2 Infection During Pregnancy

Daniela-Eugenia Popescu
ORCID logo ,
Eugen Radu Boia
* ,
Luminita Paduraru
ORCID logo ,
Gabriela Ildiko Zonda
ORCID logo ,
Ioana Rosca
ORCID logo ,
Corina Pienar
,
Cosmin Citu
ORCID logo ,
Zoran Laurentiu Popa
,
Aniko-Maria Manea
,
Camelia Budisan
,
Mirabela Dima
,
Cezara Muresan
,
Marioara Boia
Version 1 : Received: 9 January 2024 / Approved: 9 January 2024 / Online: 9 January 2024 (05:16:19 CET)

How to cite: Popescu, D.; Boia, E.R.; Paduraru, L.; Zonda, G.I.; Rosca, I.; Pienar, C.; Citu, C.; Popa, Z.L.; Manea, A.; Budisan, C.; Dima, M.; Muresan, C.; Boia, M. Inflammatory Markers in Neonates Born to Mothers With SARS-CoV-2 Infection During Pregnancy. Preprints 2024, 2024010698. https://doi.org/10.20944/preprints202401.0698.v1 Popescu, D.; Boia, E.R.; Paduraru, L.; Zonda, G.I.; Rosca, I.; Pienar, C.; Citu, C.; Popa, Z.L.; Manea, A.; Budisan, C.; Dima, M.; Muresan, C.; Boia, M. Inflammatory Markers in Neonates Born to Mothers With SARS-CoV-2 Infection During Pregnancy. Preprints 2024, 2024010698. https://doi.org/10.20944/preprints202401.0698.v1

Abstract

The COVID-19 pandemic has raised concerns about its impact on maternal and neonatal health. This study aimed to investigate the influence of maternal COVID-19 infection during pregnancy on neonatal inflammatory parameters. A retrospective cohort study was conducted at Premiere Hospital in Timisoara between May 2021 and January 2022. Participants were categorized into two groups: the COVID-19 positive group, consisting of patients with confirmed SARS-CoV-2 in-fection during pregnancy, and the control group, which comprised COVID-19-free pregnant women. The primary outcome was the assessment of inflammatory markers (NLR, dNLR, PLR, and SII) in neonates born to mothers with COVID-19. The results suggest that maternal COVID-19 infection during pregnancy significantly impacts certain neonatal inflammatory parameters. Spe-cifically, newborns exposed to maternal COVID-19 exhibited elevated white blood cell counts, particularly when infection occurred during the first trimester. Lymphocyte counts were dimin-ished in neonates born to COVID-19-positive mothers, irrespective of infection trimester. Gesta-tional age played a role in altering neonatal immune profiles, with correlations observed between GA and parameters in the Control Group (COVID-19 negative during pregnancy). However, the influence of neonatal immunoreactivity on laboratory parameters remained generally non-significant after adjusting for GA and infection trimester. In conclusion, maternal COVID-19 infection during pregnancy has a discernible impact on neonatal inflammatory parameters, in-cluding WBC and lymphocyte counts, which may have clinical implications.

Keywords

COVID-19; neonatal outcomes; inflammatory markers; maternal infection

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.