Version 1
: Received: 5 January 2024 / Approved: 8 January 2024 / Online: 8 January 2024 (12:55:37 CET)
How to cite:
Sarwar, M.S.; Mushtaq, I.; Munzoor, I. A Comprehensive Review of Wolbachia-Mediated Mechanisms to Control Dengue Virus Transmission in Aedes aegypti through Innate Immune Pathways. Preprints2024, 2024010635. https://doi.org/10.20944/preprints202401.0635.v1
Sarwar, M.S.; Mushtaq, I.; Munzoor, I. A Comprehensive Review of Wolbachia-Mediated Mechanisms to Control Dengue Virus Transmission in Aedes aegypti through Innate Immune Pathways. Preprints 2024, 2024010635. https://doi.org/10.20944/preprints202401.0635.v1
Sarwar, M.S.; Mushtaq, I.; Munzoor, I. A Comprehensive Review of Wolbachia-Mediated Mechanisms to Control Dengue Virus Transmission in Aedes aegypti through Innate Immune Pathways. Preprints2024, 2024010635. https://doi.org/10.20944/preprints202401.0635.v1
APA Style
Sarwar, M.S., Mushtaq, I., & Munzoor, I. (2024). A Comprehensive Review of Wolbachia-Mediated Mechanisms to Control Dengue Virus Transmission in Aedes aegypti through Innate Immune Pathways. Preprints. https://doi.org/10.20944/preprints202401.0635.v1
Chicago/Turabian Style
Sarwar, M.S., Iqra Mushtaq and Iqra Munzoor. 2024 "A Comprehensive Review of Wolbachia-Mediated Mechanisms to Control Dengue Virus Transmission in Aedes aegypti through Innate Immune Pathways" Preprints. https://doi.org/10.20944/preprints202401.0635.v1
Abstract
Dengue virus (DENV) is spread by Aedes aegypti and causes significant global health risks. Alternative techniques are urgently needed because the current control mech-anisms are insufficient to reduce the transmission of DENV. Introducing Wolbachia pipientis into Ae. aegypti inhibits DENV transmission, however, the underlying mechanisms are still poorly understood. Innate immune effector upregulation, the regulation of autophagy, and intracellular competition between Wolbachia and DENV for lipids are among the theories for the mechanism of inhibition. Further-more, mainly three immune pathways Toll, IMD and JAK/STAT are involved in the host for the suppression of the virus. These pathways are activated by Wolbachia and DENV in the host and are responsible for the upregulation and downregulation of many genes in mosquitoes, which ultimately reduces the titer of the DENV in the host. The functioning of these immune pathways depends upon the Wolbachia, host and virus interaction. Here, we summarize the current understanding of DENV recognition by the Ae. aegypti’s immune system, aiming to create a comprehensive picture of our knowledge. Additionally, we investigated how Wolbachia regulates ac-tivation of multiple genes associated with the Toll and IMD pathway, for the reduc-tion of arboviruses.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
