Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Combining a Drug and a Nutraceutical: A New Cocrystal of Praziquantel and Curcumin

Camila Caro Garrido
* ORCID logo ,
Marie Vandooren
,
Koen Robeyns
ORCID logo ,
Damien P. Debecker
ORCID logo ,
Patricia Luis Alconero
ORCID logo ,
Tom Leyssens
* ORCID logo
Version 1 : Received: 8 January 2024 / Approved: 8 January 2024 / Online: 8 January 2024 (10:30:31 CET)

A peer-reviewed article of this Preprint also exists.

Garrido, C.C.; Vandooren, M.; Robeyns, K.; Debecker, D.P.; Luis, P.; Leyssens, T. Combining a Drug and a Nutraceutical: A New Cocrystal of Praziquantel and Curcumin. Crystals 2024, 14, 181. Garrido, C.C.; Vandooren, M.; Robeyns, K.; Debecker, D.P.; Luis, P.; Leyssens, T. Combining a Drug and a Nutraceutical: A New Cocrystal of Praziquantel and Curcumin. Crystals 2024, 14, 181.

Abstract

This study explores the cocrystallization between the drug praziquantel (PZQ) and the nutraceutical curcumin (CU). The investigation revealed two novel solid forms: a cocrystal solvate with ethyl acetate and a non-solvated cocrystal. This novel drug-nutraceutical cocrystal is identi-fied as “generally recognized as safe” (GRAS) praziquantel-curcumin-ethyl acetate (2:1:1) co-crystal solvate. This latter undergoes desolvation, leading to the formation of the praziquan-tel-curcumin (2:1) cocrystal. The cocrystal solvate has ethyl acetate molecules occupying the voids with minimal interactions within the crystal lattice. The application of heat treatment induces solvent removal and prompts the transition to the non-solvated cocrystal, as highlighted by VT-XRD. Thermal analyses demonstrate the stability of the cocrystal solvate up to approximately 100°C, beyond which it transforms into the non-solvated phase, which eventually melts at 130°C.

Keywords

Praziquantel, Curcumin, Nutraceutical, Coformer, Cocrystal Solvate, Cocrystal

Subject

Chemistry and Materials Science, Materials Science and Technology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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