Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Mammalian Cell Cytotoxicity, Antibacterial Activity, and the Properties of Methylenebis[hydroxybenzoic Acid] and Its Related zinc(II) Complex

Ayman Hussein Ahmed
* ORCID logo ,
Ibrahim O. Althobaiti
,
Marwah Aljohani
,
Ehab S Gad
,
Yazeed M. Asiri
,
Omar A. Hussein
Version 1 : Received: 26 December 2023 / Approved: 27 December 2023 / Online: 27 December 2023 (10:08:32 CET)
Version 2 : Received: 28 December 2023 / Approved: 29 December 2023 / Online: 29 December 2023 (08:10:34 CET)

A peer-reviewed article of this Preprint also exists.

Ahmed, A.H.; Althobaiti, I.O.; Aljohani, M.; Gad, E.S.; Asiri, Y.M.; Hussein, O.A. Mammalian Cell Cytotoxicity, Antibacterial Activity and the Properties of Methylenebis(Hydroxybenzoic Acid) and Its Related Zinc(II) Complex. Crystals 2024, 14, 88. Ahmed, A.H.; Althobaiti, I.O.; Aljohani, M.; Gad, E.S.; Asiri, Y.M.; Hussein, O.A. Mammalian Cell Cytotoxicity, Antibacterial Activity and the Properties of Methylenebis(Hydroxybenzoic Acid) and Its Related Zinc(II) Complex. Crystals 2024, 14, 88.

Abstract

Formaldehyde, sulfuric acid and salicylic acid were combined to create 3,3’-methylenebis[2-hydroxybenzoic acid] (MHB) ligand, which was subsequently permitted to bind with zinc ions. The ligand and its zinc (II) complex (Zn-MHB) have been described by a combination of elemental analyses, spectral (UV-Vis, IR, MS, NMR), XRD, TEM as well as TGA measurement. The ligand has been suggested to coordinate to the zinc center in tetradentate manner forming binuclear tetrahedral complex. An X-ray analysis indicated a considerable difference between MHB (crystalline) and Zn-MHB (amorphous). UV-Vis spectra were used to determine the optical properties such as bandgap, refractive index, optical conductivity and penetration depth. Possibility of employing the samples for optoelectronic applications was indicated from the band gap values which underlie the range of semiconductors. TEM revealed spherical shapes and mutation of ligand particles into nano-scale by complexation. The antimicrobial potential of the MHB towards gram-positive and negative bacterial growths has been investigated. The results suggested that it would be possible to employ MHB to stop bacterial development, particularly salmonella typhimurium. Cytotoxicity of the MHB was assessed against two types of mammalian cells: VERO (the kidney of an African green monkey) and HFB4 (human skin melanocytes). Lower sensitivity was observed in VERO cells.

Keywords

Methylenebis[hydroxybenzoic acid]; Zinc complex; Spectral Characterization; Optical properties; Biological evaluation

Subject

Chemistry and Materials Science, Inorganic and Nuclear Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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