Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Antibiotic Resistance and MecA Gene in Isolates of Staphylococcus spp. in Bats

Marcelo Aparecido Marques
,
Isabela Carvalho Dos Santos
ORCID logo ,
Matheus Henrique Soares de Camargo
,
Gustavo Manoel
,
Aline Cristiane Cechinel Assing Batista
ORCID logo ,
Francieli Gesleine Capote Bonato
,
Lisiane de Almeida Martins
,
Karina Sakumoto
,
Jaqueline Hoscheid
,
Mariana Dalmagro
ORCID logo ,
Mariana Albano
,
Lidiane Nunes Barbosa
ORCID logo ,
Daniela Dib Gonçalves
* ORCID logo
Version 1 : Received: 19 December 2023 / Approved: 20 December 2023 / Online: 20 December 2023 (15:48:26 CET)

How to cite: Marques, M.A.; Dos Santos, I.C.; Camargo, M.H.S.D.; Manoel, G.; Batista, A.C.C.A.; Bonato, F.G.C.; Martins, L.D.A.; Sakumoto, K.; Hoscheid, J.; Dalmagro, M.; Albano, M.; Barbosa, L.N.; Gonçalves, D.D. Antibiotic Resistance and MecA Gene in Isolates of Staphylococcus spp. in Bats. Preprints 2023, 2023121521. https://doi.org/10.20944/preprints202312.1521.v1 Marques, M.A.; Dos Santos, I.C.; Camargo, M.H.S.D.; Manoel, G.; Batista, A.C.C.A.; Bonato, F.G.C.; Martins, L.D.A.; Sakumoto, K.; Hoscheid, J.; Dalmagro, M.; Albano, M.; Barbosa, L.N.; Gonçalves, D.D. Antibiotic Resistance and MecA Gene in Isolates of Staphylococcus spp. in Bats. Preprints 2023, 2023121521. https://doi.org/10.20944/preprints202312.1521.v1

Abstract

Staphylococcus spp. are among the main pathogens responsible for important infections worldwide, both in humans and in domestic or wild animals. Chiropterans, popularly known as bats, inhabit natural environments and human constructions, and have been considered potential disseminators of several pathogens. Studies have shown the expression of the mecA gene in these animals, being a significant threat to One Health. The objective of this study was to determine antibiotic resistance and the presence of the mecA gene in Staphylococcus spp. isolates from bats from forest areas in the municipalities of Paraná, Brazil. A total of 87 frugivorous chiropterans belonging to the family Phyllostomidae were captured. Of these, 87 rectal and 87 oral swabs samples were collected, re-sulting in 32 Staphylococcus spp. isolates. Twenty-four isolates were characterized as coagu-lase-negative, and 8 coagulase-positive Staphylococcus spp. (STACP), which showed notable re-sistance to oxacillin (78.12%), penicillin G (65.62%) and to other antimicrobials as well. One STACP isolate was mecA-positive. Therefore, further studies are needed to elucidate the mechanisms of contamination and dissemination of these pathogens, emphasizing that anthropic actions in na-tural environments, especially those related to the use of antimicrobials, pesticides may be the main reasons for the presence of resistant bacteria in bats.

Keywords

Antibiotics; Wild animals; Resistance genes; Bats; One Health; Chiropterans

Subject

Biology and Life Sciences, Animal Science, Veterinary Science and Zoology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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