preprints.org > medicine and pharmacology > neuroscience and neurology > doi: 10.20944/preprints202312.1270.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 15 December 2023 / Approved: 18 December 2023 / Online: 18 December 2023 (13:19:39 CET)

Dysprosody is a commonly described feature of speech deterioration due to Parkinson’s disease. Descriptions of the tonal movements underlying dysprosody have been attempted but has not afforded automation. The current study assessed a fully automated acoustic analysis pipeline in terms of its ability to predict human raters’ perception of dysprosody in patients with Parkinson’s disease. Read speech samples of 68 speakers with PD (45 male and 23 female) aged 65.0±9.8 years were assessed by four human clinical experts in terms of dysprosody severity. The recordings were also submitted to a speech processing pipeline in which portions with speech were identified and provided with a parametrization of intonation. Five models were trained and tuned based on 75% of utterances and their perceptual evaluations in a 10-fold cross-validation procedure and evaluated in terms of their ability to predict the perceptual assessments of recordings not included in the training. The performances of models were compared to human raters’ agreement with the majority vote on a speech sample. The results showed that human raters’ assessments of dysprosody can be approximated by the automated procedure. Variability in pitch does not adequately describe the level of dysprosody due to Parkinson’s disease.

Automatic acoustic assessment; Dysprosody; Parkinson’s disease

Medicine and Pharmacology, Neuroscience and Neurology

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