Zięba, M.; Sikorska, W.; Musioł, M.; Janeczek, H.; Włodarczyk, J.; Pastusiak, M.; Gupta, A.; Radecka, I.; Parati, M.; Tylko, G.; Kowalczuk, M.; Adamus, G. Designing of Drug Delivery Systems to Improve the Antimicrobial Efficacy in the Periodontal Pocket Based on Biodegradable Polyesters. Int. J. Mol. Sci.2024, 25, 503.
Zięba, M.; Sikorska, W.; Musioł, M.; Janeczek, H.; Włodarczyk, J.; Pastusiak, M.; Gupta, A.; Radecka, I.; Parati, M.; Tylko, G.; Kowalczuk, M.; Adamus, G. Designing of Drug Delivery Systems to Improve the Antimicrobial Efficacy in the Periodontal Pocket Based on Biodegradable Polyesters. Int. J. Mol. Sci. 2024, 25, 503.
Zięba, M.; Sikorska, W.; Musioł, M.; Janeczek, H.; Włodarczyk, J.; Pastusiak, M.; Gupta, A.; Radecka, I.; Parati, M.; Tylko, G.; Kowalczuk, M.; Adamus, G. Designing of Drug Delivery Systems to Improve the Antimicrobial Efficacy in the Periodontal Pocket Based on Biodegradable Polyesters. Int. J. Mol. Sci.2024, 25, 503.
Zięba, M.; Sikorska, W.; Musioł, M.; Janeczek, H.; Włodarczyk, J.; Pastusiak, M.; Gupta, A.; Radecka, I.; Parati, M.; Tylko, G.; Kowalczuk, M.; Adamus, G. Designing of Drug Delivery Systems to Improve the Antimicrobial Efficacy in the Periodontal Pocket Based on Biodegradable Polyesters. Int. J. Mol. Sci. 2024, 25, 503.
Abstract
Delivery systems of the biologically active substance such as proanthocyanidins (PCAN) produced through the electrospinning method were designed using a blend of poly(L-lactide-co-glycolide) and poly[(R,S)-3-hydroxybutyrate]. The research involved the structural and thermal characteristics of the developed electrospun three-dimensional fiber matrix, as well as hydrolytic degradation tests performed on them. Additionally, the release profile of PCAN from the electrospun nonwoven was determined using UV–VIS spectroscopy. Approximately 30% of PCAN was released from the tested electrospun nonwoven during the initial 15-20 days of incubation. The chemical structure of water-soluble oligomers that were formed after the hydrolytic degradation of the developed delivery system was identified through electrospray ionization mass spectrometry. Oligomers of lactic acid and OLAGA oligocopolyester, as well as oligo-3-hydroxybutyrate terminated with hydroxyl and carboxyl end groups, were recognized as degradation products released into the water during the incubation time. It was also demonstrated that variations in the degradation rate of individual mat components influenced the degradation pattern, and the number of formed oligomers. The obtained results suggest that the incorporation of proanthocyanidins into the system slowed down the hydrolytic degradation process of the poly(L-lactide-co-glycolide)/poly[(R,S)-3-hydroxybutyrate] three-dimensional fiber matrix. In addition, in vitro cytotoxicity and antimicrobial studies advocate the use of PCAN for biomedical applications with promising antimicrobial activity.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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