A Critical Appraisal of the Protecting Activity of Polyphenolic Antioxidants Against Iatrogenic Effects of Anticancer Chemotherapeutics§

Rosa Purgatorio; Angelina Boccarelli; Leonardo Pisani; Modesto De Candia; Marco Catto; Cosimo Damiano Altomare

doi:10.20944/preprints202312.0175.v1

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preprints.org > biology and life sciences > life sciences > doi: 10.20944/preprints202312.0175.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

A Critical Appraisal of the Protecting Activity of Polyphenolic Antioxidants Against Iatrogenic Effects of Anticancer Chemotherapeutics§

Cosimo Damiano Altomare

Version 1 : Received: 3 December 2023 / Approved: 4 December 2023 / Online: 4 December 2023 (10:06:52 CET)

A peer-reviewed article of this Preprint also exists.

Purgatorio, R.; Boccarelli, A.; Pisani, L.; de Candia, M.; Catto, M.; Altomare, C.D. A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics ^#. Antioxidants 2024, 13, 133. Purgatorio, R.; Boccarelli, A.; Pisani, L.; de Candia, M.; Catto, M.; Altomare, C.D. A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics #. Antioxidants 2024, 13, 133.

Abstract

Polyphenolic compounds, encompassing flavonoids (e.g., quercetin, rutin, cyanidin) and non-flavonoids (e.g., gallic acid, resveratrol, curcumin), show several health-related beneficial effects, which include antioxidant, anti-inflammatory, hepatoprotective, antiviral, and anticar-cinogenic properties, as well as the prevention of coronary heart diseases. Polyphenols have been also investigated for their counteraction against adverse effects of common anticancer chemo-therapeutics. This review examines the outcomes of clinical studies (and related preclinical data) over the last ten years, with a focus on the use of polyphenols in chemotherapy as auxiliary agents acting against oxidative stress toxicity induced by antitumor drugs. While further clinical studies are needed to establish adequate doses and optimal delivery systems, the improvement in pol-yphenols’ metabolic stability and bioavailability, through implementation of nanotechnologies currently being investigated, could improve therapeutic applications of their pharmaceutical or nutraceutical preparations in tumor chemotherapy.

Keywords

polyphenols; chemotherapy adjuvants; oxidative stress; cardiac toxicity

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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