Targets and Effects of Common Biocompounds of Hibiscus sabdariffa (Delphinidn-3-Sambubiosidin, Quercetin, and Hibiscus Acid) in Different Pathways of Human Cells According to a Bioinformatic Assay

Sergio Raúl Zúñiga-Hernández; Trinidad García-Iglesias; Monserrat Macías-Carballo; Alejandro Pérez-Larios; Yanet Karina Gutiérrez-Mercado; Gabriela Camargo-Hernández; Christian Martin Rodríguez-Razón

doi:10.20944/preprints202312.0162.v1

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preprints.org > medicine and pharmacology > dietetics and nutrition > doi: 10.20944/preprints202312.0162.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Targets and Effects of Common Biocompounds of Hibiscus sabdariffa (Delphinidn-3-Sambubiosidin, Quercetin, and Hibiscus Acid) in Different Pathways of Human Cells According to a Bioinformatic Assay

Sergio Raúl Zúñiga-Hernández

^* ,

Trinidad García-Iglesias

Monserrat Macías-Carballo

Alejandro Pérez-Larios

Yanet Karina Gutiérrez-Mercado

Gabriela Camargo-Hernández

Christian Martin Rodríguez-Razón

Version 1 : Received: 1 December 2023 / Approved: 4 December 2023 / Online: 5 December 2023 (06:11:11 CET)

A peer-reviewed article of this Preprint also exists.

Zúñiga-Hernández, S.R.; García-Iglesias, T.; Macías-Carballo, M.; Pérez-Larios, A.; Gutiérrez-Mercado, Y.K.; Camargo-Hernández, G.; Rodríguez-Razón, C.M. Targets and Effects of Common Biocompounds of Hibiscus sabdariffa (Delphinidin-3-Sambubiosid, Quercetin, and Hibiscus Acid) in Different Pathways of Human Cells According to a Bioinformatic Assay. Nutrients 2024, 16, 566. Zúñiga-Hernández, S.R.; García-Iglesias, T.; Macías-Carballo, M.; Pérez-Larios, A.; Gutiérrez-Mercado, Y.K.; Camargo-Hernández, G.; Rodríguez-Razón, C.M. Targets and Effects of Common Biocompounds of Hibiscus sabdariffa (Delphinidin-3-Sambubiosid, Quercetin, and Hibiscus Acid) in Different Pathways of Human Cells According to a Bioinformatic Assay. Nutrients 2024, 16, 566.

Abstract

The historical and cultural use of food as a remedy for diseases is evident in societies, such as using Hibiscus sabdariffa to address conditions like hypertension and high blood glucose. The natural biocompounds in this plant, including Delphinidin-3-Sambubioside (DS3), Quercetin (QRC), and Hibiscus Acid (HA), have been linked to various health benefits. Despite individual attention, molecular targets for these compounds remain unclear. In this study, in-silico analysis employed bioinformatic tools; including Swiss Target Prediction, ShinnyGo 0.77, KEGG, and Stringdb, to identify molecular targets, pathways, and hub genes. A PubMed literature search complemented the results. DS3 demonstrated potential modifications in genes related to nitrogen and glucose metabolism, inflammation, angiogenesis, and cell proliferation, particularly affecting the PI3K-AKT pathway. QRC displayed interconnected targets across multiple pathways, with overlap with DS3 and a focus on cancer-related pathways. HA showed distinct targets, particularly associated with nervous system-related pathways. These findings highlight the need for targeted research on the molecular effects of DS3, QRC, and HA, providing valuable insights into potential therapeutic pathways.

Keywords

Delphinidin-3-sambubiosid; Quercetin; Hibiscus Acid; Bioinformatics; Hibiscus sabdariffa

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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