Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

MVA-ST Vaccination in an Aged-Hamster Model for COVID-19 Overcomes Age-Related Immune Dysfunction and Robustly Activates T Cells and Antibodies

Sabrina Clever
,
Lisa-Marie Schünemann
,
Federico Armando
ORCID logo ,
Christian Meyer zu Natrup
,
Tamara Tuchel
,
Alina Tscherne
ORCID logo ,
Malgorzata Ciurkiewicz
,
Wolfgang Baumgärtner
ORCID logo ,
Gerd Sutter Sutter
ORCID logo ,
Asisa Volz
*
Version 1 : Received: 28 November 2023 / Approved: 29 November 2023 / Online: 29 November 2023 (12:19:37 CET)

A peer-reviewed article of this Preprint also exists.

Clever, S.; Schünemann, L.-M.; Armando, F.; Meyer zu Natrup, C.; Tuchel, T.; Tscherne, A.; Ciurkiewicz, M.; Baumgärtner, W.; Sutter, G.; Volz, A. Protective MVA-ST Vaccination Robustly Activates T Cells and Antibodies in an Aged-Hamster Model for COVID-19. Vaccines 2024, 12, 52. Clever, S.; Schünemann, L.-M.; Armando, F.; Meyer zu Natrup, C.; Tuchel, T.; Tscherne, A.; Ciurkiewicz, M.; Baumgärtner, W.; Sutter, G.; Volz, A. Protective MVA-ST Vaccination Robustly Activates T Cells and Antibodies in an Aged-Hamster Model for COVID-19. Vaccines 2024, 12, 52.

Abstract

Aging is associated with a decline in immune system functionality. So-called immunosenescence may impair successful vaccination of elderly people. Thus, improved vaccination strategies specifically adapted to an aged immune system are required. We characterized a recombinant MVA expressing a stabilized version of SARS-CoV-2 S protein (MVA-ST) in an aged-hamster model for COVID-19. Intramuscular MVA-ST immunization resulted in protection from disease and severe lung pathology. Importantly, protection correlated with potent activation of SARS-CoV-2 specific T-cells and neutralizing antibodies. Our results suggest that MVA vector vaccines merit further evaluation as clinical candidate vaccines in elderly people to overcome limitations of age-dependent immunosenescence.

Keywords

poxvirus; recombinant vaccine; preclinical model; vaccination elderly

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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