Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

An Overview of the Influence of Breastfeeding on the Developement of Inflammatory Bowel Disease

Benjamin Bertin
ORCID logo ,
Benoît Foligné
ORCID logo ,
Delphine Ley
,
Jean Lesage
ORCID logo ,
Laurent Béghin
,
Jules Morcel
ORCID logo ,
Frédéric Gottrand
,
Emmanuel Hermann
* ORCID logo
Version 1 : Received: 22 November 2023 / Approved: 24 November 2023 / Online: 26 November 2023 (06:05:40 CET)

A peer-reviewed article of this Preprint also exists.

Bertin, B.; Foligne, B.; Ley, D.; Lesage, J.; Beghin, L.; Morcel, J.; Gottrand, F.; Hermann, E. An Overview of the Influence of Breastfeeding on the Development of Inflammatory Bowel Disease. Nutrients 2023, 15, 5103. Bertin, B.; Foligne, B.; Ley, D.; Lesage, J.; Beghin, L.; Morcel, J.; Gottrand, F.; Hermann, E. An Overview of the Influence of Breastfeeding on the Development of Inflammatory Bowel Disease. Nutrients 2023, 15, 5103.

Abstract

The first 1000 days of life is a critical period that contributes significantly to the programming of an individual's future health. Among the many changes that occur during this period, there is growing evidence that the establishment of a healthy gut microbiota early in life plays an important role in the prevention of both short- and long-term health problems. Numerous publications suggest that the quality of gut microbiota colonization depends on several dietary factors, including breastfeeding. In this respect, a relationship between breastfeeding and the risk of inflammatory bowel disease (IBD) has been suggested. IBD are chronic intestinal diseases in which perinatal factors may be partly responsible for its onset. We propose to review the existence of links between breastfeeding and IBD, based on experimental and clinical studies. Overall, despite encouraging experimental data in rodents, the association between breastfeeding and the development of IBD remains controversial in humans, partly due to considerable heterogeneity between clinical studies. The duration of exclusive breastfeeding is probably decisive for its lasting effect on IBD. Thus, specific improvements in our knowledge could support dietary interventions targeting the gut microbiome, such as the early use of prebiotics, probiotics or postbiotics in order to prevent the disease.

Keywords

Early life; Breastfeeding; Milk; Microbiota; Immune system; Inflammatory Bowel Diseases

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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