Diniz, L.P.M.; Cavalcante, T.C.F.; da Silva, A.A.M. Comparative Analysis of the GH/IGF-1 Axis during the First Sixth Months in Children with Low Birth Weight. Children2023, 10, 1842.
Diniz, L.P.M.; Cavalcante, T.C.F.; da Silva, A.A.M. Comparative Analysis of the GH/IGF-1 Axis during the First Sixth Months in Children with Low Birth Weight. Children 2023, 10, 1842.
Diniz, L.P.M.; Cavalcante, T.C.F.; da Silva, A.A.M. Comparative Analysis of the GH/IGF-1 Axis during the First Sixth Months in Children with Low Birth Weight. Children2023, 10, 1842.
Diniz, L.P.M.; Cavalcante, T.C.F.; da Silva, A.A.M. Comparative Analysis of the GH/IGF-1 Axis during the First Sixth Months in Children with Low Birth Weight. Children 2023, 10, 1842.
Abstract
Objective: To analyze the relation between alterations in the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis during the first 6 months of life and weight in children born in the Lower Middle São Francisco region.
Methods: This is an analytical cohort, with a quantitative approach and a translational perspective. Thirty children with low and normal birth weight were initially identified in a hospital and reapproached at 3 and 6 months of age. Birth weight and alterations in GH/IGF-1 curves at birth, third month, and sixth month of life.
Results: Weight gain during the 6 months of follow-up in newborns with low birth weight was greater compared to newborns with normal birth weight. All children who were born with low birth weight had an altered GH/IGF-1 curve at birth (p = 0.002). Most newborns with low birth weight maintained the alteration in the GH/IGF-1 curve at the third month of life (p = 0.027). Regarding the GH/IGF-1 curve at the sixth month, alteration persisted in greater proportion among children with low birth weight.
Conclusion: Alterations in insulin resistance markers, demonstrated by increased GH without a proportional increase in IGF-1, were observed to be significant in children with low birth weight, with greater adiposity in this group, which may increase the risk of metabolic diseases in later life.
Copyright:
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