SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies

Na Li; Xiaodan Li; Yifu Ding; Xiao Liu; Karin Diggle; Tatiana Kisseleva; David A Brenner

doi:10.20944/preprints202310.2022.v1

A peer-reviewed article of this Preprint also exists.

Li, N.; Li, X.; Ding, Y.; Liu, X.; Diggle, K.; Kisseleva, T.; Brenner, D.A. SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies. Biomedicines 2023, 11, 3280. Li, N.; Li, X.; Ding, Y.; Liu, X.; Diggle, K.; Kisseleva, T.; Brenner, D.A. SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies. Biomedicines 2023, 11, 3280.

Abstract

Sterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate genes involved in the biogenesis of cholesterol, fatty acids, and triglycerides. SREBPs are involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma (HCC). We review the mechanisms by which SREBPs regulate lipogenesis, the alterations in these processes associated with liver diseases, and therapeutic strategies to target these pathways.

Keywords

SREBPs; NAFLD; NASH; fibrosis; hepatocellular carcinoma (HCC); lipogenesis, endoplasmic reticulum (ER) stress; therapeutic target

Subject

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies

Abstract

Keywords

Subject

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