Ömeroğlu, E.; Ünlü, Y.; Uğur Kılınç, A.N.; Günler, T.; Günenc, O. Histopathologic and Preneoplastic Changes in Tubal Ligation Materials. Medicina2023, 59, 2117.
Ömeroğlu, E.; Ünlü, Y.; Uğur Kılınç, A.N.; Günler, T.; Günenc, O. Histopathologic and Preneoplastic Changes in Tubal Ligation Materials. Medicina 2023, 59, 2117.
Ömeroğlu, E.; Ünlü, Y.; Uğur Kılınç, A.N.; Günler, T.; Günenc, O. Histopathologic and Preneoplastic Changes in Tubal Ligation Materials. Medicina2023, 59, 2117.
Ömeroğlu, E.; Ünlü, Y.; Uğur Kılınç, A.N.; Günler, T.; Günenc, O. Histopathologic and Preneoplastic Changes in Tubal Ligation Materials. Medicina 2023, 59, 2117.
Abstract
Abstract
Objectives
To investigate histopathological changes and serous carcinoma precursors such as secretory cell outgrowths (SCOUTs) and p53 signature in bilateral tubal ligation (BTL) materials performed during cesarean section (S/C).
Materials and Methods
138 patients who underwent S/C and tubal sterilization (TS) between October 2020 and May 2021 at Konya City Hospital. Patients’ data were obtained from the haospital’s system. All data andd findings were investigated and statistically evaluated.
Results
The mean age was 34.62 years (22 - 44), the mean gravity was 4.89 (2-15) and the mean parity was 3.46 (1-10). 5.79% SCOUT, 7.24% atypia and 9.42% p53 signatures were observed. Significant correlations were shown between epithelial cell lineage and age and between KI-67, SCOUT, and gravity, between KI-67 results and gravity and parity, and between P53 score and age.
Conclusion
TS is a common, safe, and effective method worldwide. Today, BTL is increasing along with increasing S/C ratios. In addition to the reduced risk of ovarian cancers with ligation alone, precursor lesions such as hyperplasia, SCOUT, p53 signature, and STIL/ Serous tubal intraepithelial carcinoma (STIC) are encountered in the ampulla materials obtained. Considering the low rates of re-anastomosis, tubal excision may be recommended instead of ligation in women of relatively higher gravity and age.
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
