The Inhibition Effect and Mechanism of Staurosporine Isolated from Streptomyces sp. SNC087 Strain on Nasal Polyp

Grace Choi; Eun-Young Lee; Dawoon Chung; Kichul Cho; Woon-Jong Yu; Sang-Jip Nam; Seong Kook Park; Il-Whan Choi

doi:10.20944/preprints202310.0877.v1

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preprints.org > medicine and pharmacology > medicine and pharmacology > doi: 10.20944/preprints202310.0877.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Inhibition Effect and Mechanism of Staurosporine Isolated from Streptomyces sp. SNC087 Strain on Nasal Polyp

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Version 1 : Received: 13 October 2023 / Approved: 13 October 2023 / Online: 13 October 2023 (11:35:22 CEST)

A peer-reviewed article of this Preprint also exists.

Choi, G.; Lee, E.-Y.; Chung, D.; Cho, K.; Yu, W.-J.; Nam, S.-J.; Park, S.-K.; Choi, I.-W. The Inhibition Effect and Mechanism of Staurosporine Isolated from Streptomyces Sp. SNC087 Strain on Nasal Polyp. Marine Drugs 2024, 22, 39, doi:10.3390/md22010039. Choi, G.; Lee, E.-Y.; Chung, D.; Cho, K.; Yu, W.-J.; Nam, S.-J.; Park, S.-K.; Choi, I.-W. The Inhibition Effect and Mechanism of Staurosporine Isolated from Streptomyces Sp. SNC087 Strain on Nasal Polyp. Marine Drugs 2024, 22, 39, doi:10.3390/md22010039.

Abstract

This study aims to explore the potential inhibition effects of staurosporine isolated from a Strepto-myces sp. SNC087 strain obtained from seawater on nasal polyps. Staurosporine possesses antimi-crobial and antihypertensive activities. This research focuses on investigating the effects of stau-rosporine on suppressing the growth and development of nasal polyps and elucidating the un-derlying mechanisms involved. The experimental design includes in vitro and ex vivo evaluations to assess the inhibition activity and therapeutic potential of staurosporine against nasal polyps. Nasal polyp-derived fibroblasts (NPDFs) were stimulated with TGF- β1 in the presence of staurosporine. The levels of -smooth muscle actin (-SMA), collagen type-I (Col-1), fibronectin, and phosphory-lated (p)-Smad 2 were investigated using western blotting. VEGF expression levels were analyzed in nasal polyp organ cultures treated with staurosporine. TGF-β1 stimulated the production of Col-1, fibronectin, and -SMA and was attenuated by staurosporine pretreatment. Furthermore, these inhibitory effects were mediated by modulation of the signaling pathway of Smad 2 in TGF-β1-induced NPDFs. Staurosporine also inhibits the production of VEGF in ex vivo NP tissues. The findings from this study will contribute to a better understanding of staurosporine’s role in nasal polyp management and provide insights into its mechanisms of action.

Keywords

staurosporine; nasal polys; ECM proteins; myofibroblast differentiation; Streptomyces sp. SNC087

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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