Nie, M.; Ji, Q.; Guo, G.; Zhang, H.; Wang, Y.; Zhai, R.; Pan, L. Alleviating Effect of Lactiplantibacillus plantarum NXU0011 Fermented Wolfberry on Ulcerative Colitis in Mice. Fermentation2023, 9, 971.
Nie, M.; Ji, Q.; Guo, G.; Zhang, H.; Wang, Y.; Zhai, R.; Pan, L. Alleviating Effect of Lactiplantibacillus plantarum NXU0011 Fermented Wolfberry on Ulcerative Colitis in Mice. Fermentation 2023, 9, 971.
Nie, M.; Ji, Q.; Guo, G.; Zhang, H.; Wang, Y.; Zhai, R.; Pan, L. Alleviating Effect of Lactiplantibacillus plantarum NXU0011 Fermented Wolfberry on Ulcerative Colitis in Mice. Fermentation2023, 9, 971.
Nie, M.; Ji, Q.; Guo, G.; Zhang, H.; Wang, Y.; Zhai, R.; Pan, L. Alleviating Effect of Lactiplantibacillus plantarum NXU0011 Fermented Wolfberry on Ulcerative Colitis in Mice. Fermentation 2023, 9, 971.
Abstract
As research into the relationship between the gut microbiome and health continues to evolve, probiotics are garnering increasing interest among consumers. Fermentation is rec-ognized as an efficacious biotechnology for augmenting the nutritional and functional at-tributes of foods. In this study, the ameliorative effects of Lycium barbarum L. lyophilized powder fermented with Lactobacillus plantarum NXU0011 (LP+Ly) on dextran sodium sul-fate (DSS)-induced ulcerative colitis (UC) in mice were investigated employing immuno-histochemistry, qRT-PCR, macrogenomics, and metabolomics. The results revealed that LP+Ly intervention significantly ameliorated histopathological inflammation in the ulcer-ated colon, diminished the expression of inflammatory markers such as IL-6, P-STAT3, and miR-214, and enhanced the diversity of intestinal flora in the mouse model group. Moreover, there was an increase in abundance of beneficial bacteria, including Lactobacillus, Prevotella, and Akkermansia. Metabolomic analysis indicated that 15 metabolites, including citrulline, D-xylose, and α-ketoisovaleric acid, exhibited significant variations following LP+Ly inter-vention. The metabolic pathways that displayed substantial differences included tryptophan biosynthesis, arginine biosynthesis, and amino sugar and nucleotide sugar metabolism. By modulating arginine biosynthesis, LP+Ly effectively improved the intestinal inflammatory state, thus mitigating the effects of UC.
Biology and Life Sciences, Food Science and Technology
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