Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical Assessment of Plaque Removal using a Novel Dentifrice containing Cellulose Microfibrils

Mohamed E. Labib
* ORCID logo ,
Antonio Perazzo
,
James Manganaro
,
Yacoob Tabani
,
Kimberly R. Milleman
,
Jeffery L. Milleman
,
Laurence James Walsh
ORCID logo
Version 1 : Received: 4 October 2023 / Approved: 5 October 2023 / Online: 6 October 2023 (11:28:12 CEST)

A peer-reviewed article of this Preprint also exists.

Labib, M.E.; Perazzo, A.; Manganaro, J.; Tabani, Y.; Milleman, K.R.; Milleman, J.L.; Walsh, L.J. Clinical Assessment of Plaque Removal Using a Novel Dentifrice Containing Cellulose Microfibrils. Dent. J. 2024, 12, 7. Labib, M.E.; Perazzo, A.; Manganaro, J.; Tabani, Y.; Milleman, K.R.; Milleman, J.L.; Walsh, L.J. Clinical Assessment of Plaque Removal Using a Novel Dentifrice Containing Cellulose Microfibrils. Dent. J. 2024, 12, 7.

Abstract

Dentifrice performance in the removal of dental plaque is influenced by the interactions of dentifrice components with tooth surfaces. This randomized controlled clinical study assessed the effectiveness and safety of a novel fluoride dentifrice formulation that included a micro-fibrillated cellulose network with entangled microcrystalline cellulose and silica particles (ProtegeraTM), and compared this to a positive control fluoride dentifrice (Crest Cavity Protection™). Whole mouth dental plaque levels in 82 healthy adults were measured after the first supervised use, and following a week of twice daily use at home. Overall, the novel dentifrice was at least three times more effective in whole mouth plaque reductions than the reference dentifrice (p < 0.001), with a 38.6% reduction on first use, a 30.9% reduction at day 7, and a 41.6% reduction from day 1 to day 7, compared to reductions of 12.0%, 9.6%, and 11.6% respectively for the positive control. No safety issues arose from the use of the novel dentifrice. These results indicate that including micro-fibrillated cellulose enhances plaque removal effectiveness, without causing adverse changes to oral soft tissues.

Keywords

oral hygiene; dentifrices; cellulose; nanoparticles; dental plaque

Subject

Public Health and Healthcare, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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