Composite Remineralization of Bone-Collagen Matrices: A New Approach to the Creation of Highly Effective Osteoplastic Materials

Irina S. Fadeeva; Vladislav V. Minaychev; Anastasia Yu. Teterina; Polina V. Smirnova; Ksenia A. Menshikh; Anatoliy S. Senotov; Margarita I. Kobyakova; Yana V. Lomovskaya; Igor V. Smirnov; Olga A. Krasnova; Alyona I. Zvyagina; Mikhail A. Shlykov; Kira V. Pyatina; Kirill S. Krasnov; Roman S. Fadeev; Vladimir S. Akatov; Vladimir S. Komlev

doi:10.20944/preprints202309.1989.v1

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preprints.org > chemistry and materials science > biomaterials > doi: 10.20944/preprints202309.1989.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Composite Remineralization of Bone-Collagen Matrices: A New Approach to the Creation of Highly Effective Osteoplastic Materials

Irina S. Fadeeva

^* ,

Vladislav V. Minaychev

Anastasia Yu. Teterina

^* ,

Polina V. Smirnova

Ksenia A. Menshikh

Anatoliy S. Senotov

Margarita I. Kobyakova

Version 1 : Received: 27 September 2023 / Approved: 28 September 2023 / Online: 28 September 2023 (11:17:19 CEST)

How to cite: Fadeeva, I.S.; Minaychev, V.V.; Teterina, A.Y.; Smirnova, P.V.; Menshikh, K.A.; Senotov, A.S.; Kobyakova, M.I.; Lomovskaya, Y.V.; Smirnov, I.V.; Krasnova, O.A.; Zvyagina, A.I.; Shlykov, M.A.; Pyatina, K.V.; Krasnov, K.S.; Fadeev, R.S.; Akatov, V.S.; Komlev, V.S. Composite Remineralization of Bone-Collagen Matrices: A New Approach to the Creation of Highly Effective Osteoplastic Materials. Preprints 2023, 2023091989. https://doi.org/10.20944/preprints202309.1989.v1 Fadeeva, I.S.; Minaychev, V.V.; Teterina, A.Y.; Smirnova, P.V.; Menshikh, K.A.; Senotov, A.S.; Kobyakova, M.I.; Lomovskaya, Y.V.; Smirnov, I.V.; Krasnova, O.A.; Zvyagina, A.I.; Shlykov, M.A.; Pyatina, K.V.; Krasnov, K.S.; Fadeev, R.S.; Akatov, V.S.; Komlev, V.S. Composite Remineralization of Bone-Collagen Matrices: A New Approach to the Creation of Highly Effective Osteoplastic Materials. Preprints 2023, 2023091989. https://doi.org/10.20944/preprints202309.1989.v1

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MDPI and ACS Style

Fadeeva, I.S.; Minaychev, V.V.; Teterina, A.Y.; Smirnova, P.V.; Menshikh, K.A.; Senotov, A.S.; Kobyakova, M.I.; Lomovskaya, Y.V.; Smirnov, I.V.; Krasnova, O.A.; Zvyagina, A.I.; Shlykov, M.A.; Pyatina, K.V.; Krasnov, K.S.; Fadeev, R.S.; Akatov, V.S.; Komlev, V.S. Composite Remineralization of Bone-Collagen Matrices: A New Approach to the Creation of Highly Effective Osteoplastic Materials. Preprints 2023, 2023091989. https://doi.org/10.20944/preprints202309.1989.v1

APA Style

Fadeeva, I.S., Minaychev, V.V., Teterina, A.Y., Smirnova, P.V., Menshikh, K.A., Senotov, A.S., Kobyakova, M.I., Lomovskaya, Y.V., Smirnov, I.V., Krasnova, O.A., Zvyagina, A.I., Shlykov, M.A., Pyatina, K.V., Krasnov, K.S., Fadeev, R.S., Akatov, V.S., & Komlev, V.S. (2023). Composite Remineralization of Bone-Collagen Matrices: A New Approach to the Creation of Highly Effective Osteoplastic Materials. Preprints. https://doi.org/10.20944/preprints202309.1989.v1

Chicago/Turabian Style

Fadeeva, I.S., Vladimir S. Akatov and Vladimir S. Komlev. 2023 "Composite Remineralization of Bone-Collagen Matrices: A New Approach to the Creation of Highly Effective Osteoplastic Materials" Preprints. https://doi.org/10.20944/preprints202309.1989.v1

Abstract

In the present study, the efficiency of a biomimetic approach by coating demineralized bone matrix (DBM) amorphous calcium phosphate (DBM+CaP), including its combination with serum albumin (DBM+CaP+BSA), was investigated. The intact structure of DBM promotes the transformation of amorphous calcium phosphate (CaP) into DPCD with a characteristic plate shape and particle size of 5–35 µm. The inclusion of BSA in the coating resulted in a better and more uniform distribution of CaP on the surface of DBM trabeculae. MG63 cells showed that both the obtained forms of CaP and its complex with BSA did not exhibit cytotoxicity up to a concentration of 10 mg/ml in vitro. Ectopic (subcutaneous) implantation in rats revealed pronounced biocompatibility, as well as strong osteoconductive, osteoinductive, and osteogenic effects for both DBM+CaP and DBM+CaP+BSA, but more pronounced effects for DBM+CaP+BSA. In addition, for the DBM+CaP+BSA samples, a pronounced full physiological intrafibrillar biomineralization and proangiogenic effect with the formation of bone-morrow-like niches, accompanied by pronounced processes of intramedullary hematopoiesis, indicating a powerful osteogenic effect of this composite have been achieved.

Keywords

bioactive materials; bone grafts; remineralization; coatings; bone tissue engineering; demineralized bone matrix; biomimetic scaffolds; calcium phosphate-albumin composite; bone marrow biomimetic

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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