Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Reverse Onco-Cardiology: What Is the Evidence for Breast Cancer? A Systematic Review of the Literature

IOANNIS BOUTAS
* ORCID logo ,
Adamantia Kontogeorgi
,
Sophia N Kalantaridou
ORCID logo ,
Constantine Dimitrakakis
,
Panagiotis Patsios
,
Maria Kalantzi
,
Theodoros Xanthos
ORCID logo
Version 1 : Received: 27 September 2023 / Approved: 27 September 2023 / Online: 28 September 2023 (18:13:37 CEST)

A peer-reviewed article of this Preprint also exists.

Boutas, I.; Kontogeorgi, A.; Kalantaridou, S.N.; Dimitrakakis, C.; Patsios, P.; Kalantzi, M.; Xanthos, T. Reverse Onco-Cardiology: What Is the Evidence for Breast Cancer? A Systematic Review of the Literature. International Journal of Molecular Sciences 2023, 24, 16500, doi:10.3390/ijms242216500. Boutas, I.; Kontogeorgi, A.; Kalantaridou, S.N.; Dimitrakakis, C.; Patsios, P.; Kalantzi, M.; Xanthos, T. Reverse Onco-Cardiology: What Is the Evidence for Breast Cancer? A Systematic Review of the Literature. International Journal of Molecular Sciences 2023, 24, 16500, doi:10.3390/ijms242216500.

Abstract

Breast cancer and cardiovascular diseases (CVD) represent significant global health challenges, with CVD being the leading cause of mortality and breast cancer showing a complex pattern of incidence and mortality. We explore the intricate interplay between these two seemingly distinct medical conditions, shedding light on their shared risk factors and potential pathophysiological connections. A specific connection between hypertension (HTN), atrial fibrillation (AF), myocardial infarction (MI), and breast cancer was evaluated. HTN is explored in detail, emphasizing the role of aging, menopause, insulin resistance, and obesity as common factors linking HTN and breast cancer. Moreover, an attempt is made to identify the potential impact of antihypertensive medications and highlight the increased risk of breast cancer among those women, with a focus on potential mechanisms. A summary of key findings underscores the need for a multisystemic approach to understanding the relationship between CVD and breast cancer is also explored with a highlight for all the gaps in current research, such as the lack of clinical observational data on MI and breast cancer in humans and the need for studies specifically designed for breast cancer. This paper concludes that there should be a focus on potential clinical applications of further investigation in this field, including personalized prevention and screening strategies for women at risk. Overall, the authors attempt to provide a comprehensive overview of the intricate connections between breast cancer and cardiovascular diseases, emphasizing the importance of further research in this evolving field of cardio-oncology.

Keywords

breast cancer; cardiovascular Disease; hypertension; atrial Fibrillation; myocardial Infarction

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.