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Gene Expression Analysis Reveals the Regulatory Effect of Ficus carica Latex on Cell Cycle Progression in Human Papillomavirus Positive Cervical Cancer Cell Lines
Cakir, M.O.; Bilge, U.; Ghanbari, A.; Ashrafi, G.H. Gene Expression Analysis Reveals the Regulatory Effect of Ficus carica Latex on Cell Cycle Progression in Human Papillomavirus Positive Cervical Cancer Cell Lines. Preprints2023, 2023091172. https://doi.org/10.20944/preprints202309.1172.v1
APA Style
Cakir, M.O., Bilge, U., Ghanbari, A., & Ashrafi, G.H. (2023). Gene Expression Analysis Reveals the Regulatory Effect of <em>Ficus carica</em> Latex on Cell Cycle Progression in Human Papillomavirus Positive Cervical Cancer Cell Lines. Preprints. https://doi.org/10.20944/preprints202309.1172.v1
Chicago/Turabian Style
Cakir, M.O., Arshia Ghanbari and G Hossein Ashrafi. 2023 "Gene Expression Analysis Reveals the Regulatory Effect of <em>Ficus carica</em> Latex on Cell Cycle Progression in Human Papillomavirus Positive Cervical Cancer Cell Lines" Preprints. https://doi.org/10.20944/preprints202309.1172.v1
Abstract
Cervical cancer presents a significant global health concern with high-risk human papilloma-viruses (HPVs) being identified as the cause of this cancer. Although current treatment methods for cervical cancer can eliminate lesions, preventing metastatic spread and minimizing tissue damage remains a major challenge. Therefore, the development of a safer and innovative thera-peutic approach is of utmost importance. Natural products like Fig latex, derived from the Ficus Carica tree, have demonstrated promising anti-cancer properties when tested on cervical cancer cell lines. However, the specific mechanisms by which Fig latex exerts its effects are still un-known. In this study, we conducted RNA-seq analysis to explore how Fig latex may counteract carcinogenesis in HPV-positive cervical cancer cell lines, namely CaSki (HPV type 16-positive) and HeLa (HPV type 18-positive). Our data from this investigation indicates that Fig latex influ-ences the expression of genes associated with the development and progression of cervical can-cer, including pathways related to " Nonsense-Mediated Decay (NMD) "cell cycle regulation" and Transcriptional Regulation by TP53. This selective impact of Fig latex on cancer-related pathways suggests a potential novel therapeutic approach for HPV-related cervical cancer.
Keywords
HPV; Ficus carica; cervical cancer; RNA Seq
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
