Review
Version 1
Preserved in Portico This version is not peer-reviewed
An Observatory for the MET Oncogene; a Guide for Targeted Therapies
Version 1
: Received: 31 August 2023 / Approved: 1 September 2023 / Online: 1 September 2023 (10:03:30 CEST)
A peer-reviewed article of this Preprint also exists.
Altintas, D.M.; Comoglio, P.M. An Observatory for the MET Oncogene: A Guide for Targeted Therapies. Cancers 2023, 15, 4672. Altintas, D.M.; Comoglio, P.M. An Observatory for the MET Oncogene: A Guide for Targeted Therapies. Cancers 2023, 15, 4672.
Abstract
The MET proto-oncogene encodes a pivotal tyrosine kinase receptor, binding the hepatocyte growth factor (HGF, also known as scatter factor, SF) and governing essential biological processes such as organogenesis, tissue repair, and angiogenesis. The pleiotropic physiological functions of MET explain its diverse role in cancer progression in a broad range of tumors; genetic/epigenetic alterations of MET drive tumor cell dissemination, metastasis, and acquired resistance to conventional and targeted therapies. Therefore, targeting MET emerged as a promising strategy, and many efforts were devoted to identifying the optimal way of hampering MET signaling. Despite encouraging results, however, the complexity of MET's functions in oncogenesis yields intriguing observations, fostering a humbler stance on our comprehension. This review explores recent discoveries concerning MET alterations in cancer, elucidating their biological repercussions, discussing therapeutic avenues, and outlining future directions. By contextualizing the research question and articulating the study's purpose, this work navigates MET biology's intricacies in cancer, offering a comprehensive perspective.
Keywords
MET alterations; cancer progression; invasive growth; therapeutic targeting.
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
