Enzymatic Glycosylation Strategies in the Production of Bioactive Compounds

Alicia Andreu; Marija Ćorović; Carla Garcia-Sanz; A. Sofia Santos; Ana Milivojević; Clara Ortega-Nieto; Cesar Mateo; Dejan Bezbradica; Jose M. Palomo

doi:10.20944/preprints202308.2181.v1

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preprints.org > biology and life sciences > biology and biotechnology > doi: 10.20944/preprints202308.2181.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Enzymatic Glycosylation Strategies in the Production of Bioactive Compounds

Version 1 : Received: 29 August 2023 / Approved: 29 August 2023 / Online: 31 August 2023 (12:15:05 CEST)

A peer-reviewed article of this Preprint also exists.

Andreu, A.; Ćorović, M.; Garcia-Sanz, C.; Santos, A.S.; Milivojević, A.; Ortega-Nieto, C.; Mateo, C.; Bezbradica, D.; Palomo, J.M. Enzymatic Glycosylation Strategies in the Production of Bioactive Compounds. Catalysts 2023, 13, 1359. Andreu, A.; Ćorović, M.; Garcia-Sanz, C.; Santos, A.S.; Milivojević, A.; Ortega-Nieto, C.; Mateo, C.; Bezbradica, D.; Palomo, J.M. Enzymatic Glycosylation Strategies in the Production of Bioactive Compounds. Catalysts 2023, 13, 1359.

Abstract

Some of the most recent advances in enzymatic glycosylation processes focused on the production of important bioactive compounds have been analyzed. The applicability of different enzymes such as glycosidases, glycosyltransferases, glycophosphorylases and glycosynthases have been de-scribed around the review article considering their advantages and disadvantages of these biocat-alysts in the stereoselective and regioselective synthesis of different types of glycosylated mole-cules, phenolic and aliphatic alcohols, oligosaccharides, polysaccharides, glycoderivatives, glyco-peptides and glycoproteins with a clear focus on food and pharmaceutical chemistry. Therefore, these approaches combining the use of different catalytic systems, the improvement of tools such as immobilization technology, or chemical or genetic modification to improve the synthesization in the glycosylation process could be a very useful tool in a continuous biotechnological advance.

Keywords

enzymes; glycosylation; oligosaccharides; glycoderivatives

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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