Version 1
: Received: 30 August 2023 / Approved: 31 August 2023 / Online: 31 August 2023 (10:43:55 CEST)
How to cite:
Neisi, E.; Hasanvandi, S. Synthesis of a Novel Polymer- Iron (ΙΙΙ) Complex and Study of Its Anticancer Properties on A375 Melanoma Cell Line. Preprints2023, 2023082171. https://doi.org/10.20944/preprints202308.2171.v1
Neisi, E.; Hasanvandi, S. Synthesis of a Novel Polymer- Iron (ΙΙΙ) Complex and Study of Its Anticancer Properties on A375 Melanoma Cell Line. Preprints 2023, 2023082171. https://doi.org/10.20944/preprints202308.2171.v1
Neisi, E.; Hasanvandi, S. Synthesis of a Novel Polymer- Iron (ΙΙΙ) Complex and Study of Its Anticancer Properties on A375 Melanoma Cell Line. Preprints2023, 2023082171. https://doi.org/10.20944/preprints202308.2171.v1
APA Style
Neisi, E., & Hasanvandi, S. (2023). Synthesis of a Novel Polymer- Iron (ΙΙΙ) Complex and Study of Its Anticancer Properties on A375 Melanoma Cell Line. Preprints. https://doi.org/10.20944/preprints202308.2171.v1
Chicago/Turabian Style
Neisi, E. and Siavash Hasanvandi. 2023 "Synthesis of a Novel Polymer- Iron (ΙΙΙ) Complex and Study of Its Anticancer Properties on A375 Melanoma Cell Line" Preprints. https://doi.org/10.20944/preprints202308.2171.v1
Abstract
In the present study, linear novel polymer poly(1-(2-((3-amino-2-hydroxypropyl)amino)ethyl)-1'-ethyl-[4,4'-bipyridine]-1,1'-di-ium) (poly(AHAEBD)) and its complex with iron (ΙΙΙ) ([Fe(poly(AHAEBD)2].Na3) were synthesized and then their anticancer effects on A375 human malignant melanoma cells line were evaluated. The structure of the synthesized compounds was confirmed using Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (1HNMR), field emission scanning electron microscopy (FE-SEM), X-ray energy diffraction analysis (EDS) and gel permeation chromatography (GPC). Also, the cytotoxicity of cisplatin as a reference, on A375 melanoma cell line was tested. The IC50 of polymer-complex [Fe(poly(AHAEBD)2].Na3 (0.71 µg/mL), cisplatin (4.58 µg/mL) and poly(AHAEBD) (1.73 µg/mL) were obtained. Our results revealed that the polymer-complex [Fe(poly(AHAEBD)2].Na3 exhibited better performance compared to cisplatin. Furthermore, the coordination with iron (III) enhanced the cytotoxicity levels of poly(AHAEBD). According to these findings, the synthesized polymer-complex demonstrates remarkable potential as an anti-cancer agent. This study could provide the basis for future research focused on employing this new polymer-complex for in vivo testing, highlighting its potential for therapeutic applications.
Keywords
1-(2-((3-amino-2-hydroxypropyl)amino)ethyl)-1'-ethyl-[4,4'-bipyridine]-1,1'-diium; Iron Polymer-Complex; MTT; A375 cells.
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
