Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Clinical Efficacy and Openness to New Challenges of Low Dose Rate (LDR) Brachytherapy for Prostate Cancer

Manabu Kato
* ORCID logo ,
Shinichiro Higashi
,
Yusuke Sugino
ORCID logo ,
Shinya Kajiwara
,
Shiori Tanaka
,
Goshi Kitano
,
Yasuhumi Yamashita
,
Yuji Ogura
,
Hiroyuki Tachibana
,
Takahiro Kojima
,
Takahiro Inoue
Version 1 : Received: 29 August 2023 / Approved: 29 August 2023 / Online: 30 August 2023 (09:50:47 CEST)

A peer-reviewed article of this Preprint also exists.

Kato, M.; Higashi, S.; Sugino, Y.; Kajiwara, S.; Tanaka, S.; Kitano, G.; Yamashita, Y.; Ogura, Y.; Tachibana, H.; Kojima, T.; Inoue, T. Clinical Efficacy and Openness to New Challenges of Low Dose Rate Brachytherapy for Prostate Cancer. Curr. Oncol. 2023, 30, 9824-9835. Kato, M.; Higashi, S.; Sugino, Y.; Kajiwara, S.; Tanaka, S.; Kitano, G.; Yamashita, Y.; Ogura, Y.; Tachibana, H.; Kojima, T.; Inoue, T. Clinical Efficacy and Openness to New Challenges of Low Dose Rate Brachytherapy for Prostate Cancer. Curr. Oncol. 2023, 30, 9824-9835.

Abstract

Over a century ago, low-dose-rate (LDR) brachytherapy was introduced to treat prostate cancer (PCa). Since then, it has been widely applied worldwide, including in East Asia. LDR brachythera-py has been performed in 88 institutes in Japan. Beneficial clinical outcomes of LDR brachytherapy for intermediate-to-high-risk PCa have been demonstrated in large clinical trials. These clinical outcomes were achieved through advances in methods, such as urological precise needle puncture and seed placement, and the quantitative decision-making regarding radiological parameters by radiation oncologists. Combined use of LDR brachytherapy with other therapeutical modalities, such as external beam radiation and androgen deprivation therapy, for clinical risk classification of PCa has led to better anticancer treatment efficacy. In this study, we summarized basic LDR brachytherapy findings that should remain unchanged and be passed down in urology depart-ments. We also discussed the applications of LDR brachytherapy for PCa in various clinical settings, including focal and salvage therapies. In addition, we highlighted technologies associated with brachytherapy that are under development.

Keywords

prostate cancer; brachytherapy; low dose rate brachytherapy, tri-modality therapy, salvage brachytherapy, focal brachytherapy

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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