NPAS2, A Circadian Hemeprotein and Gas-Responsive Transcription Factor

Emanuele Murgo; Tommaso Colangelo; Maria Marina Bellet; Francesco Malatesta; Gianluigi Mazzoccoli

doi:10.20944/preprints202308.1730.v1

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preprints.org > biology and life sciences > biology and biotechnology > doi: 10.20944/preprints202308.1730.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

NPAS2, A Circadian Hemeprotein and Gas-Responsive Transcription Factor

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These authors contributed equally.

Version 1 : Received: 23 August 2023 / Approved: 24 August 2023 / Online: 24 August 2023 (10:07:49 CEST)

A peer-reviewed article of this Preprint also exists.

Murgo, E.; Colangelo, T.; Bellet, M.M.; Malatesta, F.; Mazzoccoli, G. Role of the Circadian Gas-Responsive Hemeprotein NPAS2 in Physiology and Pathology. Biology 2023, 12, 1354. Murgo, E.; Colangelo, T.; Bellet, M.M.; Malatesta, F.; Mazzoccoli, G. Role of the Circadian Gas-Responsive Hemeprotein NPAS2 in Physiology and Pathology. Biology 2023, 12, 1354.

Abstract

Neuronal PAS domain protein 2 (NPAS2) is a hemeprotein comprising a basic helix-loop-helix domain (bHLH) and two heme-binding sites, the PAS-A and PAS-B domains. This protein acts as a pyridine nucleotide-dependent and gas-responsive CO-dependent transcription factor and is encoded by a gene whose expression fluctuates with circadian rhythmicity. NPAS2 can heterodimerize with ARNTL in the activating limb of the transcriptional/translational feedback loop operating the circadian clock circuitry. NPAS2 can functionally substitute for the core transcription factor and histone/protein acetylase CLOCK in the molecular clockwork endowing central oscillators in the suprachiasmatic nuclei of hypothalamus as well as in peripheral oscillators in the cell of other body tissues, such as the liver and kidney.

Keywords

NPAS2; circadian; rhythmicity; biological clock; PAS-domain

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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