Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Cytokine Profile in Lung Cancer Patients: Anti-tumor and Oncogenic Cytokines

Essogmo Freddy Elad
ORCID logo ,
Zhilenkova Angelina V.
,
Abah Moses Owoicho
ORCID logo ,
Ngaha Tchawe Yvan Sinclair
ORCID logo ,
Alexander S. Rusanov
,
Alexander Boroda
,
Yuliya N. Pirogova
,
Zaiana D. Sangadzhieva
,
Varvara D. Sanikovich
,
Nikolay N. Bagmet
,
Marina I. Sekacheva
*
Version 1 : Received: 23 August 2023 / Approved: 23 August 2023 / Online: 23 August 2023 (09:55:37 CEST)

A peer-reviewed article of this Preprint also exists.

Essogmo, F.E.; Zhilenkova, A.V.; Tchawe, Y.S.N.; Owoicho, A.M.; Rusanov, A.S.; Boroda, A.; Pirogova, Y.N.; Sangadzhieva, Z.D.; Sanikovich, V.D.; Bagmet, N.N.; Sekacheva, M.I. Cytokine Profile in Lung Cancer Patients: Anti-Tumor and Oncogenic Cytokines. Cancers 2023, 15, 5383. Essogmo, F.E.; Zhilenkova, A.V.; Tchawe, Y.S.N.; Owoicho, A.M.; Rusanov, A.S.; Boroda, A.; Pirogova, Y.N.; Sangadzhieva, Z.D.; Sanikovich, V.D.; Bagmet, N.N.; Sekacheva, M.I. Cytokine Profile in Lung Cancer Patients: Anti-Tumor and Oncogenic Cytokines. Cancers 2023, 15, 5383.

Abstract

Lung cancer accounts for the majority of cancer cases. In recent years, checkpoint inhibitor immunotherapy (ICI) has emerged as a new treatment. A better understanding of the tumor microenvironment, or TMJ, or the immune system surrounding the tumor is needed. Cytokines are small proteins that carry messages between cells and are known to play an important role in the body's response to inflammation and infection. Cytokines are important for immunity in lung cancer. It promotes tumor growth (oncogenic cytokines) or inhibits tumor growth (anti-tumor cytokines) by controlling signaling pathways for growth, proliferation, metastasis, and apoptosis. The immune system relies heavily on cytokines. They can also be produced in the laboratory for therapeutic use. Cytokine therapy helps the immune system stop the growth or kill cancer cells. Interleukins and interferons are two types of cytokines used to treat cancer. This article begins by addressing the role of the tumor microenvironment (TMJ) and its components in lung cancer. This review also highlights the functions of various cytokines such as IL, TGF and TNF.

Keywords

Lung cancer; Cytokines; Therapy; Immune system; Anti-tumor

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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