PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
The Maternal/Fetal, Newborn Exposure to Certain Antibiotics, Might Promote ASD-Related Dysbiosis in European Countries; Supporting Experimental Observations
Version 1
: Received: 22 August 2023 / Approved: 23 August 2023 / Online: 23 August 2023 (07:15:02 CEST)
How to cite:
Gábor, T.; Németh, M.; Márovics, G.; Bogár, L. The Maternal/Fetal, Newborn Exposure to Certain Antibiotics, Might Promote ASD-Related Dysbiosis in European Countries; Supporting Experimental Observations. Preprints2023, 2023081625. https://doi.org/10.20944/preprints202308.1625.v1
Gábor, T.; Németh, M.; Márovics, G.; Bogár, L. The Maternal/Fetal, Newborn Exposure to Certain Antibiotics, Might Promote ASD-Related Dysbiosis in European Countries; Supporting Experimental Observations. Preprints 2023, 2023081625. https://doi.org/10.20944/preprints202308.1625.v1
Gábor, T.; Németh, M.; Márovics, G.; Bogár, L. The Maternal/Fetal, Newborn Exposure to Certain Antibiotics, Might Promote ASD-Related Dysbiosis in European Countries; Supporting Experimental Observations. Preprints2023, 2023081625. https://doi.org/10.20944/preprints202308.1625.v1
APA Style
Gábor, T., Németh, M., Márovics, G., & Bogár, L. (2023). The Maternal/Fetal, Newborn Exposure to Certain Antibiotics, Might Promote ASD-Related Dysbiosis in European Countries; Supporting Experimental Observations. Preprints. https://doi.org/10.20944/preprints202308.1625.v1
Chicago/Turabian Style
Gábor, T., Gergely Márovics and Lajos Bogár. 2023 "The Maternal/Fetal, Newborn Exposure to Certain Antibiotics, Might Promote ASD-Related Dysbiosis in European Countries; Supporting Experimental Observations" Preprints. https://doi.org/10.20944/preprints202308.1625.v1
Abstract
Abstract: Autism spectrum disorders (ASDs) are complex, lifelong, neurodevelopmental conditions of largely unknown cause. The global prevalence of autism has increased twentyfold to thirtyfold since the earliest epidemiologic studies were conducted in the late 1960s and early 1970s. Recent reports agree on the association of ASD with the alteration of the microbiome (dysbiosis), which raises the possible role of external factors. Our study aimed at identifying antibiotic classes that might be associated with the development of ASD-related dysbiosis either promoting or inhibiting the process. Statistical comparison was made between the average yearly consumption of different antibiotic classes (1997-2020) and the number of individuals living with ASD estimated for 2023/100000 population in 30 European countries and the results were statistically analyzed. Tetracycline (J01A) showed significant positive (promoting) association with the prevalence of ASD (Pearson r: 0.373, p: 0.043. OR: 1.312, CI95%: 0.995-1.791, p: 0.065) and narrow-spectrum, beta-lactamase resistant penicillin (J01CF) (Pearson r: 0.524, p: 0.003, OR: 3.240, CI95%: 1.710-8.853, p: 0.004, Kruskal-Wallis p: 0.032). Mild, negative (inhibitory) association was observed with broad-spectrum, beta-lactamase sensitive penicillin (J01CA) (Pearson r: -0.278, p: 0.157, OR: 0.808, CI95%: 0649-0957, p: 0.028) and narrow-spectrum, beta-lactamase-sensitive penicillin (J01CE) (Pearson p: -0.032, r: 0.865, OR: 0.725, CI95%: 0.543-0.885, p: 0,009). Our findings strongly support the animal experiments when penicillin-exposed newborn mice developed "autism-like" behavior.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
